Sequential Asymptomatic Enterovirus Infections in a Patient with Major Histocompatibility Complex Class II Primary Immunodeficiency.

Nadia Driss (1) , Fethi Mellouli (2) , Ahlem Ben Yahia (1) , Henda Touzi (1) , Mohamed-Ridha Barbouche (3) , Henda Triki (1) , Mohamed Bejaoui (2)

1 Laboratoire de Virologie Clinique, Référence Régional OMS pour la Poliomyélite et la Rougeole - Laboratory of Clinical Virology, WHO Regional Reference Laboratory on Poliomyelitis and Measles
2 Pediatrics Department, Bone Marrow Transplantation Center, Tunis, Tunisia.
3 Laboratoire d'immunologie clinique [Institut Pasteur de Tunis]

Patients with primary immunodeficiencies are usually susceptible to enterovirus infections and have higher risks to develop severe clinical forms. We report a unique description of a boy with major histocompatibility complex class II (MHC-II) deficiency infected by 9 different enterovirus serotypes during a 2-year period, with very mild clinical symptoms, probably due to the immunoglobulin therapy he was receiving.

Domains: Life Sciences [q-bio]; Immunology

Nadia Driss, Fethi Mellouli, Ahlem Ben Yahia, Henda Touzi, Mohamed-Ridha Barbouche, et al.. Sequential Asymptomatic Enterovirus Infections in a Patient with Major Histocompatibility Complex Class II Primary Immunodeficiency.. Journal of Clinical Microbiology, 2014, 52 (9), pp.3486-9. ⟨10.1128/JCM.01122-14⟩. ⟨pasteur-01059885⟩