Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.

Haifa Guettiti; Emma Ennaifer; Leila Attia; Dalenda Chelly; Nissaf Ben Alaya; Rim Ben Aissa; Thalja Laassili; Samir Boubaker

Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.

Haifa Guettiti ^{1, *} Emma Ennaifer ¹ Leila Attia ² Dalenda Chelly ³ Nissaf Ben Alaya ⁴ Rim Ben Aissa ⁵ Thalja Laassili ⁶ Samir Boubaker ¹

* Corresponding author

1 Institut Pasteur de Tunis

2 Department of Gynecology

3 Department of Gynecology Centre de maternité et de Néonatologie Tunis

4 Department of Epidemiology, Observatoire National de Tunis

5 Family Planning Clinic of Ariana Tunis, Tunisia

6 Laboratoire d’Anatomie Pathologique Humaine et Expérimentale

Abstract : To estimate the pre-vaccination distribution of human papillomavirus (HPV) types among women from urban Tunis. Materials and Methods: A total of 611 women aged 18-69 years were enrolled in three local gynaecological outpatient departments. All underwent a gynaecological examination with Pap test and dry swab for HPV detection and typing performed by linear array genotyping test (Roche). Cytological examination was conducted on conventional Pap smears. Results: HPV DNA was found in 6.5% of the women; the most frequent HPV types were HPV 16 and HPV 11 at 3.27% and 1.96%, respectively. The second most frequent high risk (HR) HPV type was HPV 58 (0.82%) followed by HPV 18, HPV 31 and HPV 33 found in only 0.33% of women. Single infections with HPV types, targeted by the quadrivalent vaccine (6, 11, 16, and 18), were detected in 3.6 % of the study patients (55% of positive women). HPV infection was found in 3.83% of women with normal cytology and in 47.4% of women with cytological abnormalities. No statistically significant trend in prevalence by age group emerged for any HPV type or for high or low risk types. Conclusions: These data show a relatively low prevalence of HPV infection in women from urban Tunis with a high proportion of HPV16 and HPV58. This should be considered in the upcoming screening programs and vaccination strategy.

Keywords : vaccination strategy Human papillomavirus pap smears urban Tunis

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Life Sciences [q-bio] / Immunology

Life Sciences [q-bio] / Immunology / Vaccinology

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Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.

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Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.

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