Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.
Résumé
To estimate the pre-vaccination distribution of human papillomavirus (HPV) types among
women from urban Tunis. Materials and Methods: A total of 611 women aged 18-69 years were enrolled in
three local gynaecological outpatient departments. All underwent a gynaecological examination with Pap test
and dry swab for HPV detection and typing performed by linear array genotyping test (Roche). Cytological
examination was conducted on conventional Pap smears. Results: HPV DNA was found in 6.5% of the women;
the most frequent HPV types were HPV 16 and HPV 11 at 3.27% and 1.96%, respectively. The second most
frequent high risk (HR) HPV type was HPV 58 (0.82%) followed by HPV 18, HPV 31 and HPV 33 found in
only 0.33% of women. Single infections with HPV types, targeted by the quadrivalent vaccine (6, 11, 16, and
18), were detected in 3.6 % of the study patients (55% of positive women). HPV infection was found in 3.83% of
women with normal cytology and in 47.4% of women with cytological abnormalities. No statistically significant
trend in prevalence by age group emerged for any HPV type or for high or low risk types. Conclusions: These
data show a relatively low prevalence of HPV infection in women from urban Tunis with a high proportion of
HPV16 and HPV58. This should be considered in the upcoming screening programs and vaccination strategy.
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