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Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World.

Erhan Yalcindag 1 Virginie Rougeron 2 Eric Elguero 1 Céline Arnathau 2 Durand Patrick 2 Sylvain Brisse 3 Laure Diancourt 3 Agnès Aubouy 4 Pierre Becquart 1 Umberto d'Alessandro 5 Didier Fontenille 1 Dionicia Gamboa 6 Amanda Maestre 7 Didier Ménard 8 Lise Musset 9 Oscar Noya 10, 11 Vincent Veron Albina Wide 10, 11 Bernard Carme 12 Eric Legrand 9 Christine Chevillon 13 Francisco J Ayala 14 François Renaud 1 Franck Prugnolle 1
1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
2 MIVEGEC-HEAT - Health, Emergence, Adaptation and Transmission
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
3 Génotypage des Eucaryotes (Plate-Forme)
4 Unité de Recherche 010
5 Department of Parasitology
6 IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"
7 Grupo Salud y Comunidad
8 Laboratoire d'épidémiologie moléculaire
9 Institut Pasteur de la Guyane
10 Centro para Estudios Sobre Malaria [Venezuela]
11 IMT - Instituto de Medicina Tropical [Caracas, Venezuela}
12 Centre d’Investigation Clinique Epidémiologie clinique
13 MIVEGEC-EVCO - Evolution of host-microbe communities
PEEC - Processus Écologiques et Évolutifs au sein des Communautés
14 Department of Ecology and Evolutionary Biology
Abstract : Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa, Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins) that likely exerted new selective pressures on the parasite's genome. Among the genes that might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte-binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. In this study, we analysed, in South America, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in African populations. The aim was to determine whether these genes faced selective pressures in South America distinct from what they experienced in Africa. Patterns of genetic variability of these genes were compared to the patterns observed at two housekeeping genes (adsl and serca) and 272 SNPs to separate adaptive effects from demographic effects. We show that, conversely to Africa, eba-140 seemed to be under stronger diversifying selection in South America than eba-175. In contrast, eba-181 did not show any sign of departure from neutrality. These changes in the patterns of selection on the eba genes could be the consequence of changes in the host immune response, the host receptor polymorphisms and/or the ability of the parasite to silence or express differentially its invasion proteins.
Keywords : balancing selection co-evolution
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-01109668
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Submitted on : Monday, January 26, 2015 - 4:56:06 PM
Last modification on : Tuesday, November 16, 2021 - 12:52:02 PM

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RIIP | RIIP_CAMBODGE | RIIP_GUYANE | CNRS | PASTEUR | AGROPOLIS | B3ESTE | UNIV-MONTPELLIER | ANR

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Erhan Yalcindag, Virginie Rougeron, Eric Elguero, Céline Arnathau, Durand Patrick, et al.. Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World.. Molecular Ecology Notes, Wiley-Blackwell, 2014, 23 (8), pp.1979-93. ⟨10.1111/mec.12696⟩. ⟨pasteur-01109668⟩

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