Effects of mefloquine use on Plasmodium vivax multidrug resistance.

Nimol Khim 1 Voahangy Andrianaranjaka 2 Jean Popovici 1 Saorin Kim 1 Arsene Ratsimbasoa 3 Christophe Benedet 1 Celine Barnadas 4, 5 Remy Durand 6 Marc Thellier 7 Eric Legrand 8 Lise Musset 8 Michela Menegon 9 Carlo Severini 9 Bakri y M Nour 10 Magali Tichit 11 Christiane Bouchier 12 Odile Mercereau-Puijalon 11 Didier Ménard 1, *
* Corresponding author
1 Laboratoire d'épidémiologie moléculaire
2 Institut Pasteur de Madagascar
3 Université d'Antananarivo
4 The Walter and Eliza Hall Institute of Medical Research
5 University of Melbourne
6 Laboratoire de Parasitologie-Mycologie
7 Service de parasitologie - mycologie [CHU Pitié-Salpétrière]
8 Institut Pasteur de la Guyane
9 Department of Infectious, Parasitic and Immunomediated Diseases
10 Department of Parasitology
11 Immunologie moléculaire des parasites
12 Génomique (Plate-Forme)
Abstract : Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose non-P. falciparum parasites to mefloquine. To assess the consequences of such unintentional treatments on P. vivax, we studied variations in number of Pvmdr-1 (PlasmoDB accession no. PVX_080100, NCBI reference sequence NC_009915.1) copies worldwide in 607 samples collected in areas with different histories of mefloquine use from residents and from travelers returning to France. Number of Pvmdr-1 copies correlated with drug use history. Treatment against P. falciparum exerts substantial collateral pressure against sympatric P. vivax, jeopardizing future use of mefloquine against P. vivax. A drug policy is needed that takes into consideration all co-endemic species of malaria parasites.
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Journal articles
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Submitted on : Monday, January 26, 2015 - 5:23:57 PM
Last modification on : Tuesday, February 26, 2019 - 10:12:39 AM

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Nimol Khim, Voahangy Andrianaranjaka, Jean Popovici, Saorin Kim, Arsene Ratsimbasoa, et al.. Effects of mefloquine use on Plasmodium vivax multidrug resistance.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2014, 20 (10), pp.1637-44. ⟨10.3201/eid2010.140411⟩. ⟨pasteur-01109696⟩

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