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Journal articles
Effects of mefloquine use on Plasmodium vivax multidrug resistance.
Nimol Khim
1
Voahangy Andrianaranjaka
2
Jean Popovici
1
Saorin Kim
1
Arsene Ratsimbasoa
3
Christophe Benedet
1
Celine Barnadas
4, 5
Remy Durand
6
Marc Thellier
7
Eric Legrand
8
Lise Musset
8
Michela Menegon
9
Carlo Severini
9
Bakri y M Nour
10
Magali Tichit
11
Christiane Bouchier
12
Odile Mercereau-Puijalon
11
Didier Ménard
1, *
*
Corresponding author
Arsene Ratsimbasoa 3
Author
Christophe Benedet 1
Author
Celine Barnadas 4, 5
Author
Remy Durand 6
Author
Marc Thellier 7
Author
Eric Legrand 8
Author
Lise Musset 8
Author IdHAL : lise-musset ORCID : https://orcid.org/0000-0003-0215-4110
Michela Menegon 9
Author
Carlo Severini 9
Author
Bakri y M Nour 10
Author
Magali Tichit 11
Author
Christiane Bouchier 12
Author
Odile Mercereau-Puijalon 11
Author
Didier Ménard 1
Correspondent author IdHAL : didier-menard ORCID : https://orcid.org/0000-0003-1357-4495
1
Laboratoire d'épidémiologie moléculaire (5 bd Monivong, BP 983, Phnom Penh - Cambodia)
- Institut Pasteur du Cambodge (BP 983 - 5 , Boulevard Monivong, Phnom Penh - Cambodia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Institut Pasteur de Madagascar (B.P. 1274 Antananarivo - Madagascar)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
3
Université d'Antananarivo (BP 566 - Antananarivo 101 - Madagascar - Madagascar)
4
WEHI - The Walter and Eliza Hall Institute of Medical Research (1G Royal Parade Parkville Victoria 3052 - Australia)
5
University of Melbourne (Parkville VIC 3010 - Australia)
6
Laboratoire de Parasitologie-Mycologie (Hôpital Avicenne, 125 rue de Stalingrad, 93009, Bobigny Cedex - France)
7
Service de parasitologie - mycologie [CHU Pitié-Salpétrière] (47-83, boulevard de l'Hôpital 75013 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- CHU Pitié-Salpêtrière [AP-HP] (47-83 Boulevard de l'Hôpital, 75013 Paris - France)
- Sorbonne Université (France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
8
Institut Pasteur de la Guyane (23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex - French Guiana)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
10
Department of Parasitology (Sudan)
11
Immunologie moléculaire des parasites (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : UMR2581 (France)
12
Génomique (Plate-Forme) - Genomics Platform (Pôle BIOMICS, CITECH
28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : Numerous studies have indicated a strong association between amplification of the multidrug resistance-1 gene and in vivo and in vitro mefloquine resistance of Plasmodium falciparum. Although falciparum infection usually is not treated with mefloquine, incorrect diagnosis, high frequency of undetected mixed infections, or relapses of P. vivax infection triggered by P. falciparum infections expose non-P. falciparum parasites to mefloquine. To assess the consequences of such unintentional treatments on P. vivax, we studied variations in number of Pvmdr-1 (PlasmoDB accession no. PVX_080100, NCBI reference sequence NC_009915.1) copies worldwide in 607 samples collected in areas with different histories of mefloquine use from residents and from travelers returning to France. Number of Pvmdr-1 copies correlated with drug use history. Treatment against P. falciparum exerts substantial collateral pressure against sympatric P. vivax, jeopardizing future use of mefloquine against P. vivax. A drug policy is needed that takes into consideration all co-endemic species of malaria parasites.
Document type :
Journal articles
Complete list of metadata
https://hal-riip.archives-ouvertes.fr/pasteur-01109696
Contributor : Eric Legrand <>
Submitted on : Monday, January 26, 2015 - 5:23:57 PM
Last modification on : Monday, January 18, 2021 - 10:30:02 AM
Contributor : Eric Legrand <>
Submitted on : Monday, January 26, 2015 - 5:23:57 PM
Last modification on : Monday, January 18, 2021 - 10:30:02 AM
Links full text
Identifiers
- HAL Id : pasteur-01109696, version 1
- PUBMEDCENTRAL : PMC4193174
- PUBMED : 25272023
- DOI : 10.3201/eid2010.140411
Collections
RIIP | RIIP_CAMBODGE | RIIP_MADAGASCAR | RIIP_GUYANE | CNRS | PASTEUR | AFRIQ | SORBONNE-UNIVERSITE | SU-TI
Citation
Nimol Khim, Voahangy Andrianaranjaka, Jean Popovici, Saorin Kim, Arsene Ratsimbasoa, et al.. Effects of mefloquine use on Plasmodium vivax multidrug resistance.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2014, 20 (10), pp.1637-44. ⟨10.3201/eid2010.140411⟩. ⟨pasteur-01109696⟩
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