K. Aoyagi and M. Takahashi, Pituitary Adenylate Cyclase-Activating Polypeptide Enhances Ca2+-Dependent Neurotransmitter Release from PC12 Cells and Cultured Cerebellar Granule Cells without Affecting Intracellular Ca2+ Mobilization, Biochemical and Biophysical Research Communications, vol.286, issue.3, pp.646-651, 2001.
DOI : 10.1006/bbrc.2001.5443

M. Basille, B. J. Gonzalez, L. Desrues, M. Demas, A. Fournier et al., Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Stimulates Adenylyl Cyclase and Phospholipase C Activity in Rat Cerebellar Neuroblasts, Journal of Neurochemistry, vol.65, issue.3, pp.1318-1324, 1995.
DOI : 10.1046/j.1471-4159.1995.65031318.x

M. Basille, B. J. Gonzalez, A. Fournier, and H. Vaudry, Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in the rat cerebellum: a quantitative autoradiographic study, Developmental Brain Research, vol.82, issue.1-2, pp.81-89, 1994.
DOI : 10.1016/0165-3806(94)90150-3

M. Basille, B. J. Gonzalez, P. Leroux, L. Jeandel, A. Fournier et al., Localization and characterization of PACAP receptors in the rat cerebellum during development: Evidence for a stimulatory effect of PACAP on immature cerebellar granule cells, Neuroscience, vol.57, issue.2, pp.329-338, 1993.
DOI : 10.1016/0306-4522(93)90066-O

P. Benquet, J. Le-guen, Y. Pichon, and F. Tiaho, Differential involvement of Ca(2+) channels in survival and neurite outgrowth of cultured embryonic cockroach brain neurons, J. Neurophysiol, vol.88, pp.1475-1490, 2002.
URL : https://hal.archives-ouvertes.fr/hal-00982287

L. N. Borodinsky and M. L. Fiszman, Extracellular potassium concentration regulates proliferation of immature cerebellar granule cells, Developmental Brain Research, vol.107, issue.1, pp.43-48, 1998.
DOI : 10.1016/S0165-3806(97)00217-4

B. Botia, M. Basille, A. Allais, E. Raoult, A. Falluel-morel et al., Neurotrophic effects of PACAP in the cerebellar cortex, Peptides, vol.28, issue.9, pp.1746-1752, 2007.
DOI : 10.1016/j.peptides.2007.04.013

C. J. Bui, C. M. Beaman-hall, and M. L. Vallano, Ca2+ and CaM kinase regulate neurofilament expression, NeuroReport, vol.14, issue.16, pp.2073-2077, 2003.
DOI : 10.1097/00001756-200311140-00013

D. B. Cameron, L. Galas, Y. Jiang, E. Raoult, D. Vaudry et al., Cerebellar cortical-layer-specific control of neuronal migration by pituitary adenylate cyclase-activating polypeptide, Neuroscience, vol.146, issue.2, pp.697-712, 2007.
DOI : 10.1016/j.neuroscience.2007.02.025

B. J. Canny, S. R. Rawlings, and D. A. Leong, Pituitary adenylate cyclase-activating polypeptide specifically increases cytosolic calcium ion concentration in rat gonadotropes and somatotropes, Endocrinology, vol.130, pp.211-215, 1992.

E. Carafoli, L. Santella, D. Branca, and M. Brini, Generation, Control, and Processing of Cellular Calcium Signals, Critical Reviews in Biochemistry and Molecular Biology, vol.36, issue.2, pp.107-260, 2001.
DOI : 10.1080/20014091074183

A. Cauvin, L. Buscail, P. Gourlet, P. De-neef, D. Gossen et al., The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK, Peptides, vol.11, issue.4, pp.773-777, 1990.
DOI : 10.1016/0196-9781(90)90194-A

B. Cebolla, A. Fernandez-perez, G. Perea, A. Araque, and M. Vallejo, DREAM Mediates cAMP-Dependent, Ca2+-Induced Stimulation of GFAP Gene Expression and Regulates Cortical Astrogliogenesis, Journal of Neuroscience, vol.28, issue.26, pp.6703-6713, 2008.
DOI : 10.1523/JNEUROSCI.0215-08.2008

T. K. Chatterjee, R. V. Sharma, and R. A. Fisher, Molecular Cloning of a Novel Variant of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor That Stimulates Calcium Influx by Activation of L-type Calcium Channels, Journal of Biological Chemistry, vol.271, issue.50, pp.32226-32232, 1996.
DOI : 10.1074/jbc.271.50.32226

F. Cote, T. H. Do, L. Laflamme, J. M. Gallo, and N. Gallo-payet, Activation of the AT2 Receptor of Angiotensin II Induces Neurite Outgrowth and Cell Migration in Microexplant Cultures of the Cerebellum, Journal of Biological Chemistry, vol.274, issue.44, pp.31686-31692, 1999.
DOI : 10.1074/jbc.274.44.31686

C. Delporte, A. Van-praet, A. Herchuelz, J. Winand, C. et al., Contrasting effects of PACAP and carbachol on [Ca2+]i and inositol phosphates in human neuroblastoma NB-OK-1 cells, Peptides, vol.14, issue.6, pp.1111-1118, 1993.
DOI : 10.1016/0196-9781(93)90163-B

H. Dziema and K. Obrietan, PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway, J. Neurophysiol, vol.88, pp.1374-1386, 2002.

V. Gallo, A. Kingsbury, R. Balazs, and O. S. Jorgensen, The role of depolarization in the survival and differentiation of cerebellar granule cells in culture, J. Neurosci, vol.7, pp.2203-2213, 1987.

B. J. Gonzalez, M. Basille, D. Vaudry, A. Fournier, and H. Vaudry, Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts, Neuroscience, vol.78, issue.2, pp.419-430, 1997.
DOI : 10.1016/S0306-4522(96)00617-3

F. Gracia-navarro, M. Lamacz, M. C. Tonon, and H. Vaudry, Pituitary adenylate cyclase-activating polypeptide stimulates calcium mobilization in amphibian pituitary cells, Endocrinology, vol.131, pp.1069-1074, 1992.

M. Grimaldi, C. , and S. , Functional and molecular diversity of PACAP/VIP receptors in cortical neurons and type I astrocytes, European Journal of Neuroscience, vol.66, issue.8, pp.2767-2772, 1999.
DOI : 10.1046/j.1460-9568.1999.00693.x

I. Harfi, F. Corazza, S. D-'hondt, and E. Sariban, Differential Calcium Regulation of Proinflammatory Activities in Human Neutrophils Exposed to the Neuropeptide Pituitary Adenylate Cyclase-Activating Protein, The Journal of Immunology, vol.175, issue.6, pp.4091-4102, 2005.
DOI : 10.4049/jimmunol.175.6.4091

I. Harfi and E. Sariban, Mechanisms and modulation of pituitary adenylate cyclase-activating proteininduced calcium mobilization in human neutrophils, 2006.

A. J. Harmar, J. Fahrenkrug, I. Gozes, M. Laburthe, V. May et al., Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR Review 1, British Journal of Pharmacology, vol.123, issue.1, pp.4-17, 2012.
DOI : 10.1111/j.1476-5381.2012.01871.x

M. Hezareh, W. Schlegel, and S. R. Rawlings, PACAP and VIP stimulate Ca2+ oscillations in rat gonadotrophs through the PACAP/VIP type 1 receptor (PVR1) linked to a pertussis toxin-insensitive G-protein and the activation of phospholipase C-beta, 1996.

J. Hill, S. A. Chan, B. Kuri, and C. Smith, Pituitary Adenylate Cyclase-activating Peptide (PACAP) Recruits Low Voltage-activated T-type Calcium Influx under Acute Sympathetic Stimulation in Mouse Adrenal Chromaffin Cells, Journal of Biological Chemistry, vol.286, issue.49, pp.42459-42469, 2011.
DOI : 10.1074/jbc.M111.289389

Y. Holighaus, T. Mustafa, and L. E. Eiden, PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells, Peptides, vol.32, issue.8, pp.1647-1655, 2011.
DOI : 10.1016/j.peptides.2011.06.004

K. Isobe, T. Nakai, and Y. Takuwa, Ca(2+)-dependent stimulatory effect of pituitary adenylate cyclase-activating polypeptide on catecholamine secretion from cultured porcine adrenal medullary chromaffin cells, Endocrinology, vol.132, pp.1757-1765, 1993.

V. Jolivel, M. Basille, N. Aubert, S. De-jouffrey, P. Ancian et al., Distribution and functional characterization of pituitary adenylate cyclase???activating polypeptide receptors in the brain of non-human primates, Neuroscience, vol.160, issue.2, pp.434-451, 2009.
DOI : 10.1016/j.neuroscience.2009.02.028

URL : https://hal.archives-ouvertes.fr/pasteur-00819922

H. Kaddour, Y. Hamdi, D. Vaudry, M. Basille, L. Desrues et al., The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway, Journal of Neurochemistry, vol.10, issue.4, pp.620-633, 2013.
DOI : 10.1111/jnc.12140

P. Kienlen-campard, C. Crochemore, F. Rene, D. Monnier, B. Koch et al., PACAP Type I Receptor Activation Promotes Cerebellar Neuron Survival Through the cAMP/PKA Signaling Pathway, DNA and Cell Biology, vol.16, issue.3, pp.323-333, 1997.
DOI : 10.1089/dna.1997.16.323

M. Kokubo, M. Nishio, T. J. Ribar, K. A. Anderson, A. E. West et al., BDNF-Mediated Cerebellar Granule Cell Development Is Impaired in Mice Null for CaMKK2 or CaMKIV, Journal of Neuroscience, vol.29, issue.28, pp.8901-8913, 2009.
DOI : 10.1523/JNEUROSCI.0040-09.2009

H. Komuro, R. , and P. , Selective role of N-type calcium channels in neuronal migration, Science, vol.257, issue.5071, pp.806-809, 1992.
DOI : 10.1126/science.1323145

H. Komuro, R. , and P. , Intracellular Ca2+ Fluctuations Modulate the Rate of Neuronal Migration, Neuron, vol.17, issue.2, pp.275-285, 1996.
DOI : 10.1016/S0896-6273(00)80159-2

A. C. Levi, M. Demattei, R. Ravazzani, G. Corvetti, G. T. Golden et al., Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on ultrastructure of nigral neuromelanin in Macaca fascicularis, Neuroscience Letters, vol.96, issue.3, pp.271-276, 1989.
DOI : 10.1016/0304-3940(89)90390-X

A. J. Martinez-fuentes, J. P. Castano, M. M. Malagon, R. Vazquez-martinez, and F. Gracia-navarro, Pituitary adenylate cyclase-activating polypeptides 38 and 27 increase cytosolic free Ca2+ concentration in porcine somatotropes through common and distinct mechanisms, Cell Calcium, vol.23, issue.6, pp.369-378, 1998.
DOI : 10.1016/S0143-4160(98)90093-8

Y. Masuo, Y. Matsumoto, F. Tokito, M. Tsuda, and M. Fujino, Effects of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) on the spontaneous release of acetylcholine from the rat hippocampus by brain microdialysis, Brain Research, vol.611, issue.2, pp.207-215, 1993.
DOI : 10.1016/0006-8993(93)90504-G

K. Matsuda, Y. Nejigaki, M. Satoh, C. Shimaura, M. Tanaka et al., Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on prolactin and somatolactin release from the goldfish pituitary in vitro, Regulatory Peptides, vol.145, issue.1-3, pp.72-79, 2008.
DOI : 10.1016/j.regpep.2007.08.018

Y. A. Mei, High-voltageactivated calcium current and its modulation by dopamine D4 and pituitary adenylate cyclase activating polypeptide receptors in cerebellar granule cells, Zhongguo Yao Li Xue Bao, vol.20, pp.3-9, 1999.

S. Michel, J. Itri, J. H. Han, K. Gniotczynski, and C. S. Colwell, Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus, BMC Neuroscience, vol.7, issue.1, pp.15-25, 2006.
DOI : 10.1186/1471-2202-7-15

A. Miyata, A. Arimura, R. R. Dahl, N. Minamino, A. Uehara et al., Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells, Biochemical and Biophysical Research Communications, vol.164, issue.1, pp.567-574, 1989.
DOI : 10.1016/0006-291X(89)91757-9

T. Mustafa, M. Grimaldi, and L. E. Eiden, The Hop Cassette of the PAC1 Receptor Confers Coupling to Ca2+ Elevation Required for Pituitary Adenylate Cyclase-activating Polypeptide-evoked Neurosecretion, Journal of Biological Chemistry, vol.282, issue.11, pp.8079-8091, 2007.
DOI : 10.1074/jbc.M609638200

A. Nicot and E. Dicicco-bloom, Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression, Proceedings of the National Academy of Sciences, vol.98, issue.8, 2001.
DOI : 10.1073/pnas.071465398

A. Nicot, V. Lelievre, J. Tam, J. A. Waschek, and E. Dicicco-bloom, Pituitary adenylate cyclaseactivating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation, J. Neurosci, vol.22, pp.9244-9254, 2002.

D. F. Owens, A. C. Flint, R. S. Dammerman, and A. R. Kriegstein, Calcium Dynamics of Neocortical Ventricular Zone Cells, Developmental Neuroscience, vol.22, issue.1-2, pp.25-33, 2000.
DOI : 10.1159/000017424

G. M. Ramakers, P. Pasinelli, M. Van-beest, A. Van-der-slot, W. H. Gispen et al., Activation of pre- and postsynaptic protein kinase C during tetraethylammonium-induced long-term potentiation in the CA1 field of the hippocampus, Neuroscience Letters, vol.286, issue.1, pp.53-56, 2000.
DOI : 10.1016/S0304-3940(00)01081-8

S. R. Rawlings, B. J. Canny, and D. A. Leong, Pituitary adenylate cyclase-activating polypeptide regulates cytosolic Ca2+ in rat gonadotropes and somatotropes through different intracellular mechanisms, Endocrinology, vol.132, pp.1447-1452, 1993.

S. R. Rawlings, N. Demaurex, and W. Schlegel, Pituitary adenylate cyclase-activating polypeptide increases [Ca2]i in rat gonadotrophs through an inositol trisphosphatedependent mechanism, J. Biol. Chem, vol.269, pp.5680-5686, 1994.

D. Reglodi, P. Kiss, K. Szabadfi, T. Atlasz, R. Gabriel et al., PACAP is an Endogenous Protective Factor???Insights from PACAP-Deficient Mice, Journal of Molecular Neuroscience, vol.57, issue.3, pp.482-492, 2012.
DOI : 10.1007/s12031-012-9762-0

L. C. Ronn, S. Dissing, A. Holm, V. Berezin, and E. Bock, Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM, FEBS Letters, vol.118, issue.1-3, pp.60-66, 2002.
DOI : 10.1016/S0014-5793(02)02644-3

M. Sato, K. Suzuki, H. Yamazaki, and S. Nakanishi, A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells, Proc. Natl, 2005.
DOI : 10.1073/pnas.0501972102

N. Shintani, S. Suetake, H. Hashimoto, K. Koga, A. Kasai et al., Neuroprotective action of endogenous PACAP in cultured rat cortical neurons, Regulatory Peptides, vol.126, issue.1-2, pp.123-128, 2005.
DOI : 10.1016/j.regpep.2004.08.014

K. Tanaka, I. Shibuya, T. Nagamoto, H. Yamashita, and T. Kanno, Pituitary adenylate cyclaseactivating polypeptide causes rapid Ca2+ release from intracellular stores and long lasting Ca2+ influx mediated by Na( influx-dependent membrane depolarization in bovine adrenal chromaffin cells, Endocrinology, vol.137, pp.956-966, 1996.

I. Tatsuno and A. Arimura, Pituitary adenylate cyclase-activating polypeptide (PACAP) mobilizes intracellular free calcium in cultured rat type-2, but not type-1, astrocytes, Brain Research, vol.662, issue.1-2, pp.1-10, 1994.
DOI : 10.1016/0006-8993(94)90790-0

I. Tatsuno, T. Yada, S. Vigh, H. Hidaka, and A. Arimura, Pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide increase cytosolic free calcium concentration in cultured rat hippocampal neurons, Endocrinology, vol.131, pp.73-81, 1992.

C. P. Turner, D. Pulciani, R. , and S. A. , Reduction in Intracellular Calcium Levels Induces Injury in Developing Neurons, Experimental Neurology, vol.178, issue.1, pp.21-32, 2002.
DOI : 10.1006/exnr.2002.8027

D. Vaudry, A. Falluel-morel, S. Bourgault, M. Basille, D. Burel et al., Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery, Pharmacological Reviews, vol.61, issue.3, pp.283-357, 2009.
DOI : 10.1124/pr.109.001370

D. Vaudry, B. J. Gonzalez, M. Basille, Y. Anouar, A. Fournier et al., Pituitary adenylate cyclase-activating polypeptide stimulates both c-fos gene expression and cell survival in rat cerebellar granule neurons through activation of the protein kinase A pathway, Neuroscience, vol.84, issue.3, pp.801-812, 1998.
DOI : 10.1016/S0306-4522(97)00545-9

D. Vaudry, B. J. Gonzalez, M. Basille, A. Fournier, and H. Vaudry, Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development, Proceedings of the National Academy of Sciences, vol.96, issue.16, pp.9415-9420, 1999.
DOI : 10.1073/pnas.96.16.9415

M. Villalba, J. Bockaert, and L. Journot, Pituitary adenylate cyclaseactivating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway, J. Neurosci, vol.17, pp.83-90, 1997.

J. Voogd and M. Glickstein, The anatomy of the cerebellum, Trends in Cognitive Sciences, vol.2, issue.9, pp.307-313, 1998.
DOI : 10.1016/S1364-6613(98)01210-8

T. Watanabe, Y. Masuo, H. Matsumoto, N. Suzuki, T. Ohtaki et al., Pituitary adenylate cyclase activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline, Biochemical and Biophysical Research Communications, vol.182, issue.1, pp.403-411, 1992.
DOI : 10.1016/S0006-291X(05)80159-7

Y. Xiang, Y. Li, Z. Zhang, K. Cui, S. Wang et al., Nerve growth cone guidance mediated by G protein???coupled receptors, Nature Neuroscience, vol.5, issue.9, pp.843-848, 2002.
DOI : 10.1038/nn899

T. Yada, M. Sakurada, K. Ihida, M. Nakata, F. Murata et al., Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells, J. Biol. Chem, vol.269, pp.1290-1293, 1994.

T. Yada, S. Vigh, and A. Arimura, Pituitary adenylate cyclase activating polypeptide (PACAP) increases cytosolic-free calcium concentration in folliculo-stellate cells and somatotropes of rat pituitary, Peptides, vol.14, issue.2, pp.235-239, 1993.
DOI : 10.1016/0196-9781(93)90035-F

Y. Yan, X. Zhou, Z. Pan, J. Ma, J. A. Waschek et al., Pro- and Anti-Mitogenic Actions of Pituitary Adenylate Cyclase-Activating Polypeptide in Developing Cerebral Cortex: Potential Mediation by Developmental Switch of PAC1 Receptor mRNA Isoforms, Journal of Neuroscience, vol.33, issue.9, pp.3865-3878, 2013.
DOI : 10.1523/JNEUROSCI.1062-12.2013

C. J. Yao, C. W. Lin, and S. Y. Lin-shiau, Roles of Thapsigargin-Sensitive Ca2+ Stores in the Survival of Developing Cultured Neurons, Journal of Neurochemistry, vol.52, issue.2, pp.457-465, 1999.
DOI : 10.1046/j.1471-4159.1999.0730457.x