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Journal Articles Cell Host and Microbe Year : 2013

Leishmania dices away cholesterol for survival.

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Abstract

Host lipid alterations are centrally involved in Leishmania donovani infection, and infected patients exhibit hypocholesterolemia. In this issue of Cell Host & Microbe, Ghosh et al. (2013) show that the metalloprotease GP63 released by L. donovani in the liver cleaves DICER1, inhibiting miR-122 maturation, which regulates cholesterol metabolism. These events decrease serum cholesterol and promote parasite growth.

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pasteur-01130855 , version 1 (12-03-2015)

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Albert Descoteaux, Neda Moradin, Guillermo Arango Duque. Leishmania dices away cholesterol for survival.. Cell Host and Microbe, 2013, 13 (3), pp.245-7. ⟨10.1016/j.chom.2013.02.018⟩. ⟨pasteur-01130855⟩

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