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Leishmania dices away cholesterol for survival.

Abstract : Host lipid alterations are centrally involved in Leishmania donovani infection, and infected patients exhibit hypocholesterolemia. In this issue of Cell Host & Microbe, Ghosh et al. (2013) show that the metalloprotease GP63 released by L. donovani in the liver cleaves DICER1, inhibiting miR-122 maturation, which regulates cholesterol metabolism. These events decrease serum cholesterol and promote parasite growth.
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Submitted on : Thursday, March 12, 2015 - 2:32:38 PM
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Albert Descoteaux, Neda Moradin, Guillermo Arango Duque. Leishmania dices away cholesterol for survival.. Cell Host and Microbe, Elsevier, 2013, 13 (3), pp.245-7. ⟨10.1016/j.chom.2013.02.018⟩. ⟨pasteur-01130855⟩



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