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Journal articles
Hantavirus Gn and Gc glycoproteins self-assemble into virus-like particles.
Abstract : How hantaviruses assemble and exit infected cells remains largely unknown. Here, we show that the expression of Andes (ANDV) and Puumala (PUUV) hantavirus Gn and Gc envelope glycoproteins lead to their self-assembly into virus-like particles (VLPs) which were released to cell supernatants. The viral nucleoprotein was not required for particle formation. Further, a Gc endodomain deletion mutant did not abrogate VLP formation. The VLPs were pleomorphic, exposed protrusions and reacted with patient sera.
Cited literature [40 references]
https://hal-riip.archives-ouvertes.fr/pasteur-01134374
Contributor : Michel Courcelles <>
Submitted on : Monday, March 23, 2015 - 2:56:36 PM
Last modification on : Monday, May 25, 2020 - 8:54:02 PM
Long-term archiving on: : Thursday, July 2, 2015 - 6:27:01 AM
Contributor : Michel Courcelles <>
Submitted on : Monday, March 23, 2015 - 2:56:36 PM
Last modification on : Monday, May 25, 2020 - 8:54:02 PM
Long-term archiving on: : Thursday, July 2, 2015 - 6:27:01 AM
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J. Virol.-2014-Acuña-2344-8 ...
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