Therapeutic implications of immunogenic cell death in human cancer

Fabio Palombo (1) , Chiara Focaccetti (1) , Vincenzo Barnaba (2) , Fabio Palombo (1) , Vincenzo Barnaba (2)

1 Department of Internal Medicine and Medical Specialities
2 Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti

Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.

Keywords: dendritic cells; T cells; chemotherapy; immunogenic cell death; tumor antigens

Domains: Cancer; Immunology

Fabio Palombo, Chiara Focaccetti, Vincenzo Barnaba, Fabio Palombo, Vincenzo Barnaba. Therapeutic implications of immunogenic cell death in human cancer. Frontiers in Immunology, 2014, pp.6. ⟨10.3389/fimmu.2013.00503⟩. ⟨pasteur-01148979⟩