Therapeutic implications of immunogenic cell death in human cancer

Abstract : Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.
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Frontiers in Immunology, Frontiers, 2014, pp.6. 〈10.3389/fimmu.2013.00503〉
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Fabio Palombo, Chiara Focaccetti, Vincenzo Barnaba, Fabio Palombo, Vincenzo Barnaba. Therapeutic implications of immunogenic cell death in human cancer. Frontiers in Immunology, Frontiers, 2014, pp.6. 〈10.3389/fimmu.2013.00503〉. 〈pasteur-01148979〉

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