S. Ministero-della, Ricerca finalizzata (RFPS-2006-3-337923 and RFPS- 2007-1-636647)

P. Robbins, Y. Lu, M. El-gamil, Y. Li, C. Gross et al., Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells, Istituto Italiano di Tecnologia (IIT) (A2 project 2013, pp.747-523161, 2013.
DOI : 10.1038/nm.3161

I. Mellman and R. Steinman, Dendritic Cells, Cell, vol.106, issue.3, pp.255-263, 2001.
DOI : 10.1016/S0092-8674(01)00449-4

A. Satpathy, X. Wu, J. Albring, and K. Murphy, Re(de)fining the dendritic cell lineage, Nature Immunology, vol.180, issue.12, pp.1145-54, 2012.
DOI : 10.1073/pnas.1117359109

P. Matzinger, The Danger Model: A Renewed Sense of Self, Science, vol.296, issue.5566, pp.301-306, 2002.
DOI : 10.1126/science.1071059

D. Gabrilovich, S. Ostrand-rosenberg, and V. Bronte, Coordinated regulation of myeloid cells by tumours, Nature Reviews Immunology, vol.205, issue.4, pp.253-68, 2012.
DOI : 10.1038/nri3175

J. Banchereau and R. Steinman, Dendritic cells and the control of immunity, Nature, vol.392, issue.6673, pp.245-52, 1998.
DOI : 10.1038/32588

C. Bennett and B. Clausen, DC ablation in mice: promises, pitfalls, and challenges, Trends in Immunology, vol.28, issue.12, pp.525-556, 2007.
DOI : 10.1016/j.it.2007.08.011

B. Schraml, J. Van-blijswijk, S. Zelenay, P. Whitney, A. Filby et al., Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage, Cell, vol.154, issue.4, 2013.
DOI : 10.1016/j.cell.2013.07.014

S. Zelenay, R. Sousa, and C. , Adaptive immunity after cell death, Trends in Immunology, vol.34, issue.7, pp.329-364, 2013.
DOI : 10.1016/j.it.2013.03.005

E. Segura, M. Durand, and S. Amigorena, Similar antigen cross-presentation capacity and phagocytic functions in all freshly isolated human lymphoid organ???resident dendritic cells, The Journal of Experimental Medicine, vol.151, issue.5, pp.1035-1082, 2013.
DOI : 10.1182/blood-2010-02-258558

G. Hammer and A. Ma, Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis, Annual Review of Immunology, vol.31, issue.1, pp.743-91, 2013.
DOI : 10.1146/annurev-immunol-020711-074929

H. Hemmi, T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88???dependent signaling pathway, Nature Immunology, vol.3, issue.2, pp.196-20010, 1038.
DOI : 10.1038/ni758

K. Honda, S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai et al., Selective contribution of IFN-??/?? signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection, Proceedings of the National Academy of Sciences, vol.100, issue.19, pp.10872-10879, 2003.
DOI : 10.1073/pnas.1934678100

B. Reizis, M. Colonna, G. Trinchieri, F. Barrat, and M. Gilliet, Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?, Nature Reviews Immunology, vol.10, issue.8, pp.558-65, 2011.
DOI : 10.1038/nri3027

B. Cisse, M. Caton, M. Lehner, T. Maeda, S. Scheu et al., Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development, Cell, vol.135, issue.1, pp.37-48, 2008.
DOI : 10.1016/j.cell.2008.09.016

E. Segura, M. Touzot, A. Bohineust, A. Cappuccio, G. Chiocchia et al., Human Inflammatory Dendritic Cells Induce Th17 Cell Differentiation, Immunity, vol.38, issue.2, pp.336-384, 2013.
DOI : 10.1016/j.immuni.2012.10.018
URL : http://doi.org/10.1016/j.immuni.2012.10.018

A. Pinzon-charry, C. Ho, T. Maxwell, M. Mcguckin, C. Schmidt et al., Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer, British Journal of Cancer, vol.25, issue.9, pp.1251-1260, 2007.
DOI : 10.1007/s002620050438

I. Perrot, D. Blanchard, N. Freymond, S. Isaac, B. Guibert et al., Dendritic Cells Infiltrating Human Non-Small Cell Lung Cancer Are Blocked at Immature Stage, The Journal of Immunology, vol.178, issue.5, pp.2763-2772, 2007.
DOI : 10.4049/jimmunol.178.5.2763

G. Bellone, A. Carbone, C. Smirne, T. Scirelli, A. Buffolino et al., Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells, The Journal of Immunology, vol.177, issue.5, pp.3448-60, 2006.
DOI : 10.4049/jimmunol.177.5.3448

B. Lee, M. Follen, G. Rodriquez, D. Shen, A. Malpica et al., Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions, Cancer, vol.175, issue.5, pp.999-1007, 2006.
DOI : 10.1002/cncr.22092

L. Ormandy, A. Farber, T. Cantz, S. Petrykowska, S. Wedemeyer et al., Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma, World Journal of Gastroenterology, vol.12, issue.20, pp.3275-82, 2006.
DOI : 10.3748/wjg.v12.i20.3275

A. Pinzon-charry, C. Ho, R. Laherty, T. Maxwell, D. Walker et al., A Population of HLA-DR+ Immature Cells Accumulates in the Blood Dendritic Cell Compartment of Patients with Different Types of Cancer, Neoplasia, vol.7, issue.12, pp.1112-1134, 2005.
DOI : 10.1593/neo.05442

S. Kusmartsev, E. Eruslanov, H. Kübler, T. Tseng, Y. Sakai et al., Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma, The Journal of Immunology, vol.181, issue.1, pp.346-53, 2008.
DOI : 10.4049/jimmunol.181.1.346

L. Yang, J. Huang, X. Ren, A. Gorska, A. Chytil et al., Abrogation of TGF?? Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis, Cancer Cell, vol.13, issue.1, pp.23-35, 2008.
DOI : 10.1016/j.ccr.2007.12.004

M. Lawrence, P. Stojanov, P. Polak, G. Kryukov, K. Cibulskis et al., Mutational heterogeneity in cancer and the search for new cancer-associated genes, Nature, vol.31, issue.7457, pp.214-222, 2013.
DOI : 10.1038/nature12213

R. Spisek, A. Charalambous, A. Mazumder, D. Vesole, S. Jagannath et al., Bortezomib enhances dendritic cell (DC) mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications, Blood, vol.109, issue.11, pp.4839-4884, 2007.
DOI : 10.1182/blood-2006-10-054221

D. Krysko, A. Garg, A. Kaczmarek, O. Krysko, P. Agostinis et al., Immunogenic cell death and DAMPs in cancer therapy, Nature Reviews Cancer, vol.77, issue.12, pp.860-75, 2012.
DOI : 10.1038/nrc3380

M. Obeid, A. Tesniere, F. Ghiringhelli, G. Fimia, L. Apetoh et al., Calreticulin exposure dictates the immunogenicity of cancer cell death, Nature Medicine, vol.279, issue.1, pp.54-6110, 1038.
DOI : 10.1038/nm1523
URL : https://hal.archives-ouvertes.fr/inserm-00451702

S. Martin, C. Reutelingsperger, A. Mcgahon, J. Rader, R. Van-schie et al., Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl, Journal of Experimental Medicine, vol.182, issue.5, pp.1545-56, 1995.
DOI : 10.1084/jem.182.5.1545

T. Panaretakis, O. Kepp, U. Brockmeier, A. Tesniere, A. Bjorklund et al., Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death, The EMBO Journal, vol.65, issue.5, pp.578-90, 2009.
DOI : 10.1074/jbc.M512073200

L. Apetoh, F. Ghiringhelli, A. Tesniere, M. Obeid, C. Ortiz et al., Toll-like receptor 4???dependent contribution of the immune system to anticancer chemotherapy and radiotherapy, Nature Medicine, vol.289, issue.9, pp.1050-1059, 2007.
DOI : 10.1038/nm1622
URL : https://hal.archives-ouvertes.fr/hal-00316924

S. Jube, Z. Rivera, M. Bianchi, A. Powers, E. Wang et al., Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma, Cancer Research, vol.72, issue.13, pp.3290-301, 2012.
DOI : 10.1158/0008-5472.CAN-11-3481

E. Venereau, M. Casalgrandi, M. Schiraldi, D. Antoine, A. Cattaneo et al., Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release, The Journal of Experimental Medicine, vol.209, issue.9, pp.1519-1547, 2012.
DOI : 10.2119/molmed.2011.00389

H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-harris, E. Venereau et al., Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1), Mol Med, vol.18, pp.250-259, 2012.

Y. Ma, S. Adjemian, S. Mattarollo, T. Yamazaki, L. Aymeric et al., Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells, Immunity, vol.38, issue.4, pp.729-770, 2013.
DOI : 10.1016/j.immuni.2013.03.003

M. Michaud, I. Martins, A. Sukkurwala, S. Adjemian, Y. Ma et al., Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice, Science, vol.334, issue.6062, pp.1573-1580, 2011.
DOI : 10.1126/science.1208347

I. Martins, M. Michaud, A. Sukkurwala, S. Adjemian, Y. Ma et al., Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death, Autophagy, vol.8, issue.3, pp.413-418, 2012.
DOI : 10.4161/auto.19009

M. Ciampricotti, C. Hau, C. Doornebal, J. Jonkers, and K. De-visser, Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system, Nature Medicine, vol.18, issue.3, pp.344-350, 2012.
DOI : 10.1056/NEJMoa1104621

R. Zappasodi, S. Pupa, G. Ghedini, I. Bongarzone, M. Magni et al., Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death, Cancer Research, vol.70, issue.22, pp.9062-72, 2010.
DOI : 10.1158/0008-5472.CAN-10-1825

M. Paroli, F. Bellati, M. Videtta, C. Focaccetti, C. Mancone et al., Discovery of chemotherapy-associated ovarian cancer antigens by interrogating memory T cells, International Journal of Cancer, vol.6, issue.8, 2013.
DOI : 10.1002/ijc.28515
URL : https://hal.archives-ouvertes.fr/pasteur-01148396

P. Rawson, C. Molette, M. Videtta, L. Altieri, D. Franceschini et al., Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection, Nature Medicine, vol.162, issue.12, pp.1431-1440, 1679.
DOI : 10.1002/eji.200324539

V. Barnaba, Tuning Cross-Presentation of Apoptotic T Cells in Immunopathology, Adv Exp Med Biol, vol.785, pp.27-35, 2013.
DOI : 10.1007/978-1-4614-6217-0_3

D. Franceschini, D. Porto, P. Piconese, S. Trella, E. Accapezzato et al., Polyfunctional type-1, -2, and -17 CD8(+) T cell responses to apoptotic selfantigens correlate with the chronic evolution of hepatitis C virus infection, PLoS Pathog, 2012.
URL : https://hal.archives-ouvertes.fr/pasteur-00966408

F. Lolli, H. Martini, A. Citro, D. Franceschini, E. Portaccio et al., Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis, Journal of Neuroinflammation, vol.35, issue.1, pp.94-104, 2013.
DOI : 10.1186/1742-2094-10-94

L. Zitvogel, O. Kepp, and G. Kroemer, Immune parameters affecting the efficacy of chemotherapeutic regimens, Nature Reviews Clinical Oncology, vol.23, issue.3, 2011.
DOI : 10.1038/nrclinonc.2010.223

©. Copyright, . Palombo, . Focaccetti, and . Barnaba, This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms, Frontiers in Immunology | Tumor Immunity