Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.

Matthias Merker; Camille Blin; Stefano Mona; Nicolas Duforet-Frebourg; Sophie Lecher; Eve Willery; Michael G B Blum; Sabine Rüsch-Gerdes; Igor Mokrousov; Eman Aleksic; Caroline Allix-Béguec; Annick Antierens; Ewa Augustynowicz-Kopeć; Marie Ballif; Francesca Barletta; Hans Peter Beck; Clifton E Barry; Maryline Bonnet; Emanuele Borroni; Isolina Campos-Herrero; Daniela Cirillo; Helen Cox; Suzanne Crowe; Valeriu Crudu; Roland Diel; Francis Drobniewski; Maryse Fauville-Dufaux; Sébastien Gagneux; Solomon Ghebremichael; Madeleine Hanekom; Sven Hoffner; Wei-Wei Jiao; Stobdan Kalon; Thomas A Kohl; Irina Kontsevaya; Troels Lillebæk; Shinji Maeda; Vladyslav Nikolayevskyy; Michael Rasmussen; Nalin Rastogi; Sofia Samper; Elisabeth Sanchez-Padilla; Branislava Savic; Isdore Chola Shamputa; Adong Shen; Li-Hwei Sng; Petras Stakenas; Kadri Toit; Francis Varaine; Dragana Vukovic; Céline Wahl; Robin Warren; Philip Supply; Stefan Niemann; Thierry Wirth

doi:10.1038/ng.3195

Journal articles

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.

Matthias Merker ¹ Camille Blin ^{2, 3} Stefano Mona ^{3, 2} Nicolas Duforet-Frebourg ⁴ Sophie Lecher ⁵ Eve Willery ⁵ Michael G B Blum ⁴ Sabine Rüsch-Gerdes ⁶ Igor Mokrousov ⁷ Eman Aleksic ⁸ Caroline Allix-Béguec ⁹ Annick Antierens ¹⁰ Ewa Augustynowicz-Kopeć ¹¹ Marie Ballif ¹² Francesca Barletta ¹³ Hans Peter Beck ¹⁴ Clifton E Barry ¹⁵ Maryline Bonnet ¹⁶ Emanuele Borroni ¹⁷ Isolina Campos-Herrero ¹⁸ Daniela Cirillo ¹⁷ Helen Cox Suzanne Crowe ^{19, 8} Valeriu Crudu Roland Diel ²⁰ Francis Drobniewski ^{21, 22} Maryse Fauville-Dufaux ²³ Sébastien Gagneux ^{24, 14} Solomon Ghebremichael ²⁵ Madeleine Hanekom ²⁶ Sven Hoffner ²⁵ Wei-Wei Jiao ²⁷ Stobdan Kalon Thomas A Kohl ¹ Irina Kontsevaya ²⁸ Troels Lillebæk Shinji Maeda ²⁹ Vladyslav Nikolayevskyy ²¹ Michael Rasmussen Nalin Rastogi ³⁰ Sofia Samper ³¹ Elisabeth Sanchez-Padilla Branislava Savic Isdore Chola Shamputa ^{32, 33} Adong Shen ³⁴ Li-Hwei Sng ³⁵ Petras Stakenas Kadri Toit Francis Varaine ³⁶ Dragana Vukovic ³⁷ Céline Wahl ⁹ Robin Warren ³⁸ Philip Supply ^{5, 9} Stefan Niemann ^{39, 1} Thierry Wirth ^{40, 2, 3}

1 Molecular Mycobacteriology

2 ISYEB - Institut de Systématique, Evolution, Biodiversité

3 Laboratoire Biologie Intégrative des Population, Evolution Moléculaire

4 TIMC-IMAG-BCM - Biologie Computationnelle et Mathématique

TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525

5 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204

6 National Reference Center for Mycobacteria

7 Institut Pasteur de Saint-Pétersbourg

8 Centre for Biomedical Research

9 genoscreen

10 Medical Department

11 Department of Microbiology

12 Institute of Social and Preventive Medicine

13 Instituto de Medicina Tropical Alexander von Humboldt, Molecular Epidemiology Unit–Tuberculosis

IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"

14 MPI - Medical Parasitology and Infection Biology [Basel, Suisse]

15 LaRIA - Laboratoire de Recherche en Informatique d'Amiens

16 Epicentre [Paris] [Médecins Sans Frontières]

17 Emerging Bacterial Pathogen Unit

18 hospital Universitario de Gran Canaria Dr Negrin

19 Macfarlane Burnet Institute for Medical Research

20 JAD - Laboratoire Jean Alexandre Dieudonné

21 PHE National Mycobacterial Reference Laboratory and Clinical TB and HIV Group

22 Division of Infectious Diseases

23 CNR - Centre national de Référence et Laboratoire Tuberculose et Mycobactéries = National Reference Centre of Tuberculosis and Mycobacteria [Brussels]

24 MRC National Institute for Medical Research

25 Department of Preparedness

26 Faculty of Medicine and Health Sciences

27 Key Laboratory of Major Diseases in Children

28 Samara Oblast TB Service

29 Research institute of Tuberculosis

30 Institut Pasteur de la Guadeloupe

31 LARMAUR - LAboratoire de Recherche en Mécanique Appliquée

32 Mycobacteriology Unit

33 Microbiology Unit

34 III-V Lab - Alcatel-Thalès III-V lab

35 Central Tuberculosis Laboratory

36 Medecins Sans Frontieres - Medecins Sans Frontieres

37 DTU Fotonik - Department of Photonics Engineering

38 molecular biology and human genetics

39 Molecular Mycobacteriology Group

40 OSEB - Origine, structure et évolution de la biodiversité

Abstract : Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Santé publique et épidémiologie

Life Sciences [q-bio] / Microbiology and Parasitology / Bacteriology

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Submitted on : Wednesday, May 20, 2015 - 2:17:05 PM
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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.

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