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Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.

Matthias Merker 1 Camille Blin 2, 3 Stefano Mona 3, 2 Nicolas Duforet-Frebourg 4 Sophie Lecher 5 Eve Willery 5 Michael G B Blum 4 Sabine Rüsch-Gerdes 6 Igor Mokrousov 7 Eman Aleksic 8 Caroline Allix-Béguec 9 Annick Antierens 10 Ewa Augustynowicz-Kopeć 11 Marie Ballif 12 Francesca Barletta 13 Hans Peter Beck 14 Clifton E Barry 15 Maryline Bonnet 16 Emanuele Borroni 17 Isolina Campos-Herrero 18 Daniela Cirillo 17 Helen Cox Suzanne Crowe 19, 8 Valeriu Crudu Roland Diel 20 Francis Drobniewski 21, 22 Maryse Fauville-Dufaux 23 Sébastien Gagneux 24, 14 Solomon Ghebremichael 25 Madeleine Hanekom 26 Sven Hoffner 25 Wei-Wei Jiao 27 Stobdan Kalon Thomas A Kohl 1 Irina Kontsevaya 28 Troels Lillebæk Shinji Maeda 29 Vladyslav Nikolayevskyy 21 Michael Rasmussen Nalin Rastogi 30 Sofia Samper 31 Elisabeth Sanchez-Padilla Branislava Savic Isdore Chola Shamputa 32, 33 Adong Shen 34 Li-Hwei Sng 35 Petras Stakenas Kadri Toit Francis Varaine 36 Dragana Vukovic 37 Céline Wahl 9 Robin Warren 38 Philip Supply 5, 9 Stefan Niemann 39, 1 Thierry Wirth 40, 2, 3
1 Molecular Mycobacteriology
2 ISYEB - Institut de Systématique, Evolution, Biodiversité
3 Laboratoire Biologie Intégrative des Population, Evolution Moléculaire
4 TIMC-IMAG-BCM - Biologie Computationnelle et Mathématique
TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525
5 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
6 National Reference Center for Mycobacteria
7 Institut Pasteur de Saint-Pétersbourg
8 Centre for Biomedical Research
9 genoscreen
10 Medical Department
11 Department of Microbiology
12 Institute of Social and Preventive Medicine
13 Instituto de Medicina Tropical Alexander von Humboldt, Molecular Epidemiology Unit–Tuberculosis
IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"
14 MPI - Medical Parasitology and Infection Biology [Basel, Suisse]
15 LaRIA - Laboratoire de Recherche en Informatique d'Amiens
16 Epicentre [Paris] [Médecins Sans Frontières]
17 Emerging Bacterial Pathogen Unit
18 hospital Universitario de Gran Canaria Dr Negrin
19 Macfarlane Burnet Institute for Medical Research
20 JAD - Laboratoire Jean Alexandre Dieudonné
21 PHE National Mycobacterial Reference Laboratory and Clinical TB and HIV Group
22 Division of Infectious Diseases
23 CNR - Centre national de Référence et Laboratoire Tuberculose et Mycobactéries = National Reference Centre of Tuberculosis and Mycobacteria [Brussels]
24 MRC National Institute for Medical Research
25 Department of Preparedness
26 Faculty of Medicine and Health Sciences
27 Key Laboratory of Major Diseases in Children
28 Samara Oblast TB Service
29 Research institute of Tuberculosis
30 Institut Pasteur de la Guadeloupe
31 LARMAUR - LAboratoire de Recherche en Mécanique Appliquée
32 Mycobacteriology Unit
33 Microbiology Unit
34 III-V Lab - Alcatel-Thalès III-V lab
35 Central Tuberculosis Laboratory
36 Medecins Sans Frontieres - Medecins Sans Frontieres
37 DTU Fotonik - Department of Photonics Engineering
38 molecular biology and human genetics
39 Molecular Mycobacteriology Group
40 OSEB - Origine, structure et évolution de la biodiversité
Abstract : Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage initially originated in the Far East, from where it radiated worldwide in several waves. We detected successive increases in population size for this pathogen over the last 200 years, practically coinciding with the Industrial Revolution, the First World War and HIV epidemics. Two MDR clones of this lineage started to spread throughout central Asia and Russia concomitantly with the collapse of the public health system in the former Soviet Union. Mutations identified in genes putatively under positive selection and associated with virulence might have favored the expansion of the most successful branches of the lineage.
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https://hal-riip.archives-ouvertes.fr/pasteur-01153552
Contributor : Nalin Rastogi <>
Submitted on : Wednesday, May 20, 2015 - 2:17:05 PM
Last modification on : Wednesday, June 2, 2021 - 3:48:01 PM

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RIIP | IMAG | CNRS | UNIV-RENNES1 | EPHE | RIIP_LILLE | RIIP_SAINTPETERSBOURG | RIIP_GUADELOUPE | DIEUDONNE | UNICE | LARMAUR | UNIV-COTEDAZUR | TIMC-IMAG | TIMC-IMAG-BCM | UNIV-RENNES | UNIV-LILLE | ISYEB | SORBONNE-UNIVERSITE | MNHN | SU-SCIENCES | IPR | UR1-UFR-SPM | OSUR | CIIL | UPMC | PSL | UGA | SU-TI

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Matthias Merker, Camille Blin, Stefano Mona, Nicolas Duforet-Frebourg, Sophie Lecher, et al.. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.. Nature Genetics, Nature Publishing Group, 2015, 47 (3), pp.242-249. ⟨10.1038/ng.3195⟩. ⟨pasteur-01153552⟩

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