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The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru

Abstract : BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis. METHODS: To investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census. RESULTS: The Latin American Mediterranean (LAM) clade (OR 2.4, p<0.001) was significantly associated with drug-resistance and alone accounted for more than half of all drug resistance in the region. Previously treated patients, prisoners and genetically clustered cases were also significantly associated with drug-resistance (OR's 2.5, 2.4 and 1.8, p<0.001, p<0.05, p<0.001 respectively). CONCLUSIONS: Tuberculosis disease caused by the LAM clade was more likely to be drug resistant independent of important clinical, genetic and socio-economic confounding factors. Explanations for this include; the preferential co-evolution of LAM strains in a Latin American population, a LAM strain bacterial genetic background that favors drug-resistance or the "founder effect" from pre-existing LAM strains disproportionately exposed to drugs.
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Submitted on : Saturday, May 23, 2015 - 12:39:14 AM
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Louis Grandjean, Tomotada Iwamoto, Anna Lithgow, Robert H Gilman, Kentaro Arikawa, et al.. The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru. PLoS ONE, Public Library of Science, 2015, 10 (5), pp.e0126271. ⟨10.1371/journal.pone.0126271⟩. ⟨pasteur-01154027⟩

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