Skip to Main content Skip to Navigation
Journal articles

Long non-coding RNAs: new players in cell differentiation and development.

Abstract : Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.
Complete list of metadata

Cited literature [117 references]  Display  Hide  Download
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Thursday, June 4, 2015 - 4:41:43 PM
Last modification on : Wednesday, October 28, 2020 - 3:20:08 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Alessandro Fatica, Irene Bozzoni. Long non-coding RNAs: new players in cell differentiation and development.. Nature Reviews Genetics, Nature Publishing Group, 2014, 15 (1), pp.7-21. ⟨10.1038/nrg3606⟩. ⟨pasteur-01160208⟩



Record views