CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia.

Abstract : CCAAT/enhancer-binding protein-α (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of CEBPA transcriptional targets to the newly identified class of long non-coding RNAs. We show that lncRNAs are a main component of the transcriptional program driven by C/EBPα and that many of these are also induced during granulocytic differentiation of AML cell lines supporting their relevance in proliferation arrest and differentiation.
Keywords : AML CEBPA lncRNAs
Document type :
Journal articles
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01163656
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Monday, June 15, 2015 - 11:32:30 AM
Last modification on : Tuesday, August 13, 2019 - 12:20:21 PM
Long-term archiving on : Tuesday, April 25, 2017 - 7:56:51 AM

File

13045_2014_Article_69.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

James M Hughes, Beatrice Salvatori, Federico M Giorgi, Irene Bozzoni, Alessandro Fatica. CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia.. Journal of Hematology and Oncology, BioMed Central, 2014, 7, pp.69. ⟨10.1186/s13045-014-0069-1⟩. ⟨pasteur-01163656⟩

Share

Metrics

Record views

159

Files downloads

164