CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia. - RIIP - Réseau International des Instituts Pasteur Access content directly
Journal Articles Journal of Hematology and Oncology Year : 2014

CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia.

Abstract

CCAAT/enhancer-binding protein-α (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of CEBPA transcriptional targets to the newly identified class of long non-coding RNAs. We show that lncRNAs are a main component of the transcriptional program driven by C/EBPα and that many of these are also induced during granulocytic differentiation of AML cell lines supporting their relevance in proliferation arrest and differentiation.

Keywords

Fichier principal
Vignette du fichier
13045_2014_Article_69.pdf (596.66 Ko) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

pasteur-01163656 , version 1 (15-06-2015)

Licence

Attribution

Identifiers

Cite

James M Hughes, Beatrice Salvatori, Federico M Giorgi, Irene Bozzoni, Alessandro Fatica. CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia.. Journal of Hematology and Oncology, 2014, 7, pp.69. ⟨10.1186/s13045-014-0069-1⟩. ⟨pasteur-01163656⟩

Collections

RIIP RIIP_FCB
55 View
111 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More