J. Lazzaroni, J. Dubuisson, and A. Vianney, The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins, Biochimie, vol.84, issue.5-6, pp.391-397, 2002.
DOI : 10.1016/S0300-9084(02)01419-0

A. Bernstein, R. B. Onodera, and K. , Pleiotropic properties and genetic organization of the tolA,B locus of Escherichia coli K-12, J Bacteriol, vol.112, pp.74-83, 1972.

R. Webster, The tol gene products and the import of macronmolecules into Escherichia coli, Molecular Microbiology, vol.138, issue.5, pp.1005-1011, 1991.
DOI : 10.1073/pnas.87.12.4776

J. Lazzaroni, P. Germon, M. Ray, and A. Vianney, and their involvement in the uptake of biomolecules and outer membrane stability, FEMS Microbiology Letters, vol.177, issue.2, pp.191-197, 1999.
DOI : 10.1111/j.1574-6968.1999.tb13731.x

R. Lloubès, E. Cascales, A. Walburger, E. Bouveret, and C. Lazdunski, The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?, Research in Microbiology, vol.152, issue.6, pp.523-529, 2001.
DOI : 10.1016/S0923-2508(01)01226-8

J. Sturgis, Organisation and evolution of the tol-pal gene cluster, J Mol Microbiol Biotechnol, vol.3, pp.113-122, 2001.

E. Cascales, A. Bernadac, M. Gavioli, J. Lazzaroni, and R. Lloubes, Pal Lipoprotein of Escherichia coli Plays a Major Role in Outer Membrane Integrity, Journal of Bacteriology, vol.184, issue.3, pp.754-759, 2002.
DOI : 10.1128/JB.184.3.754-759.2002

R. Godlewska, K. Wis´niewskawis´niewska, Z. Pietras, and E. Jaqusztyn-krynicka, Peptidoglycan-associated lipoprotein (Pal) of Gram-negative bacteria: function, structure, role in pathogenesis and potential application in immunoprophylaxis, FEMS Microbiology Letters, vol.298, issue.1, pp.1-11, 2009.
DOI : 10.1111/j.1574-6968.2009.01659.x

A. Egan and W. Vollmer, The physiology of bacterial cell division, Annals of the New York Academy of Sciences, vol.77, issue.1, pp.8-28, 2013.
DOI : 10.1111/j.1749-6632.2012.06818.x

J. Dubuisson, A. Vianney, N. Hugouvieux-cotte-pattat, and J. Lazzaroni, Tol-Pal proteins are critical cell envelope components of Erwinia chrysanthemi affecting cell morphology and virulence, Microbiology, vol.151, issue.10, pp.3337-3347, 2005.
DOI : 10.1099/mic.0.28237-0

Y. Yeh, L. Comolli, K. Downing, L. Shapiro, and H. Mcadams, The Caulobacter Tol-Pal Complex Is Essential for Outer Membrane Integrity and the Positioning of a Polar Localization Factor, Journal of Bacteriology, vol.192, issue.19, pp.4847-4858, 2010.
DOI : 10.1128/JB.00607-10

F. Bowe, C. Lipps, R. Tsolis, E. Groisman, and F. Heffron, At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice, Infect Immun, vol.66, pp.3372-3377, 1998.

A. Heilpern and M. Waldor, CTXphi Infection of Vibrio cholerae Requires the tolQRA Gene Products, Journal of Bacteriology, vol.182, issue.6, pp.1739-1747, 2000.
DOI : 10.1128/JB.182.6.1739-1747.2000

M. Llamas, J. Ramos, and J. Rodríguez-herva, Mutations in Each of the tol Genes of Pseudomonas putida Reveal that They Are Critical for Maintenance of Outer Membrane Stability, Journal of Bacteriology, vol.182, issue.17, pp.4764-4772, 2000.
DOI : 10.1128/JB.182.17.4764-4772.2000

F. Imperi, F. Ciccosanti, A. Perdomo, F. Tiburzi, and C. Mancone, Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen, PROTEOMICS, vol.46, issue.7, pp.1901-1915, 2009.
DOI : 10.1002/pmic.200800618

J. Dennis, E. Lafontaine, and P. Sokol, Identification and characterization of the tolQRA genes of Pseudomonas aeruginosa., Journal of Bacteriology, vol.178, issue.24, pp.7059-7068, 1996.
DOI : 10.1128/jb.178.24.7059-7068.1996

M. Jacobs, A. Alwood, I. Thaipisuttikul, D. Spencer, and E. Haugen, Comprehensive transposon mutant library of Pseudomonas aeruginosa, Proceedings of the National Academy of Sciences, vol.100, issue.24, pp.14339-14344, 2003.
DOI : 10.1073/pnas.2036282100

N. Liberati, J. Urbach, S. Miyata, D. Lee, and E. Drenkard, An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants, Proceedings of the National Academy of Sciences, vol.103, issue.8, pp.2833-2838, 2006.
DOI : 10.1073/pnas.0511100103

D. Skurnik, D. Roux, H. Aschard, V. Cattoir, and D. Yoder-himes, A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries, PLoS Pathogens, vol.43, issue.9, p.1003582, 2013.
DOI : 10.1371/journal.ppat.1003582.s022

L. Rahme, E. Stevens, S. Wolfort, J. Shao, and R. Tompkins, Common virulence factors for bacterial pathogenicity in plants and animals, Science, vol.268, issue.5219, pp.1899-1902, 1995.
DOI : 10.1126/science.7604262

A. Bragonzi, M. Paroni, A. Nonis, N. Cramer, and S. Montanari, Microevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted Virulence, American Journal of Respiratory and Critical Care Medicine, vol.180, issue.2, pp.138-145, 2009.
DOI : 10.1164/rccm.200812-1943OC

R. Simon, U. Priefer, and A. Pühler, A Broad Host Range Mobilization System for In Vivo Genetic Engineering: Transposon Mutagenesis in Gram Negative Bacteria, Bio/Technology, vol.134, issue.9, pp.784-790, 1983.
DOI : 10.1016/0378-1119(78)90025-2

L. Liss, New M13 host: DH5 F' competent cells, Focus, vol.9, p.13, 1987.

D. Milton, O. Toole, R. Horstedt, P. Wolf-watz, and H. , Flagellin A is essential for the virulence of Vibrio anguillarum., Journal of Bacteriology, vol.178, issue.5, pp.1310-1319, 1996.
DOI : 10.1128/jb.178.5.1310-1319.1996

K. Mdluli, P. Witte, T. Kline, A. Barb, and A. Erwin, Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa, Antimicrobial Agents and Chemotherapy, vol.50, issue.6, pp.2178-2184, 2006.
DOI : 10.1128/AAC.00140-06

T. Hoang, A. Kutchma, A. Becher, and H. Schweizer, Integration-Proficient Plasmids for Pseudomonas aeruginosa: Site-Specific Integration and Use for Engineering of Reporter and Expression Strains, Plasmid, vol.43, issue.1, pp.59-72, 2000.
DOI : 10.1006/plas.1999.1441

J. Sambrook, E. Fritsch, and T. Maniatis, Molecular Cloning: A Laboratory Manual, 1989.

F. Massai, F. Imperi, S. Quattrucci, E. Zennaro, and P. Visca, A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal, Biosensors and Bioelectronics, vol.26, issue.8, pp.3444-3449, 2011.
DOI : 10.1016/j.bios.2011.01.022

L. Antunes, F. Imperi, A. Carattoli, and P. Visca, Deciphering the Multifactorial Nature of Acinetobacter baumannii Pathogenicity, PLoS ONE, vol.108, issue.8, p.22674, 2011.
DOI : 10.1371/journal.pone.0022674.s004

A. Spoering and K. Lewis, Biofilms and Planktonic Cells of Pseudomonas aeruginosa Have Similar Resistance to Killing by Antimicrobials, Journal of Bacteriology, vol.183, issue.23, pp.6746-6751, 2001.
DOI : 10.1128/JB.183.23.6746-6751.2001

J. Bulitta, J. Yang, L. Yohonn, N. Ly, and S. Brown, Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model, Antimicrobial Agents and Chemotherapy, vol.54, issue.5, pp.2051-2062, 2010.
DOI : 10.1128/AAC.00881-09

G. Jander, L. Rahme, and F. Ausubel, Positive Correlation between Virulence of Pseudomonas aeruginosa Mutants in Mice and Insects, Journal of Bacteriology, vol.182, issue.13, pp.3843-3845, 2000.
DOI : 10.1128/JB.182.13.3843-3845.2000

L. Bertuccini, M. Costanzo, F. Iosi, A. Tinari, and F. Terruzzi, Lactoferrin prevents invasion and inflammatory response following E. coli strain LF82 infection in experimental model of Crohn's disease, Digestive and Liver Disease, vol.46, issue.6, pp.496-504, 2014.
DOI : 10.1016/j.dld.2014.02.009

G. Rossolini and E. Mantengoli, Treatment and control of severe infections caused by multiresistant Pseudomonas aeruginosa, Clinical Microbiology and Infection, vol.11, pp.17-32, 2005.
DOI : 10.1111/j.1469-0691.2005.01161.x

N. Mesaros, P. Nordmann, P. Plésiat, M. Roussel-delvallez, and J. Van-eldere, Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium, Clinical Microbiology and Infection, vol.13, issue.6, pp.560-578, 2007.
DOI : 10.1111/j.1469-0691.2007.01681.x
URL : https://hal.archives-ouvertes.fr/hal-00510521

D. Livermore, Multiple Mechanisms of Antimicrobial Resistance in Pseudomonas aeruginosa: Our Worst Nightmare?, Clinical Infectious Diseases, vol.34, issue.5, pp.634-640, 2002.
DOI : 10.1086/338782

M. Vaara, Novel derivatives of polymyxins, Journal of Antimicrobial Chemotherapy, vol.68, issue.6, pp.1213-1219, 2013.
DOI : 10.1093/jac/dkt039

K. Poole, Efflux-mediated multiresistance in Gram-negative bacteria, Clinical Microbiology and Infection, vol.10, issue.1, pp.12-26, 2004.
DOI : 10.1111/j.1469-0691.2004.00763.x

K. Poole, Pseudomonas Aeruginosa: Resistance to the Max, Frontiers in Microbiology, vol.2, p.65, 2011.
DOI : 10.3389/fmicb.2011.00065

S. Gellatly and R. Hancock, : new insights into pathogenesis and host defenses, Pathogens and Disease, vol.67, issue.3, pp.159-173, 2013.
DOI : 10.1111/2049-632X.12033