Antivirulence activity of azithromycin in Pseudomonas aeruginosa.

Abstract : Antibiotics represent our bulwark to combat bacterial infections, but the spread of antibiotic resistance compromises their clinical efficacy. Alternatives to conventional antibiotics are urgently needed in order to complement the existing antibacterial arsenal. The macrolide antibiotic azithromycin (AZM) provides a paradigmatic example of an "unconventional" antibacterial drug. Besides its growth-inhibiting activity, AZM displays potent anti-inflammatory properties, as well as antivirulence activity on some intrinsically resistant bacteria, such as Pseudomonas aeruginosa. In this bacterium, the antivirulence activity of AZM mainly relies on its ability to interact with the ribosome, resulting in direct and/or indirect repression of specific subsets of genes involved in virulence, quorum sensing, biofilm formation, and intrinsic antibiotic resistance. Both clinical experience and clinical trials have shown the efficacy of AZM in the treatment of chronic pulmonary infections caused by P. aeruginosa. The aim of this review is to combine results from laboratory studies with evidence from clinical trials in order to unify the information on the in vivo mode of action of AZM in P. aeruginosa infection.
Type de document :
Article dans une revue
Frontiers in microbiology, Frontiers Research Foundation, 2014, 5, pp.178. 〈10.3389/fmicb.2014.00178〉
Liste complète des métadonnées

Littérature citée [66 références]  Voir  Masquer  Télécharger
Contributeur : Istituto Pasteur Fondazione Cenci Bolognetti <>
Soumis le : jeudi 30 juillet 2015 - 12:27:58
Dernière modification le : lundi 8 octobre 2018 - 17:44:07
Document(s) archivé(s) le : samedi 31 octobre 2015 - 10:32:33


Publication financée par une institution


Distributed under a Creative Commons Paternité 4.0 International License




Francesco Imperi, Livia Leoni, Paolo Visca. Antivirulence activity of azithromycin in Pseudomonas aeruginosa.. Frontiers in microbiology, Frontiers Research Foundation, 2014, 5, pp.178. 〈10.3389/fmicb.2014.00178〉. 〈pasteur-01181964〉



Consultations de la notice


Téléchargements de fichiers