Skip to Main content Skip to Navigation
Journal articles

Antivirulence activity of azithromycin in Pseudomonas aeruginosa.

Abstract : Antibiotics represent our bulwark to combat bacterial infections, but the spread of antibiotic resistance compromises their clinical efficacy. Alternatives to conventional antibiotics are urgently needed in order to complement the existing antibacterial arsenal. The macrolide antibiotic azithromycin (AZM) provides a paradigmatic example of an "unconventional" antibacterial drug. Besides its growth-inhibiting activity, AZM displays potent anti-inflammatory properties, as well as antivirulence activity on some intrinsically resistant bacteria, such as Pseudomonas aeruginosa. In this bacterium, the antivirulence activity of AZM mainly relies on its ability to interact with the ribosome, resulting in direct and/or indirect repression of specific subsets of genes involved in virulence, quorum sensing, biofilm formation, and intrinsic antibiotic resistance. Both clinical experience and clinical trials have shown the efficacy of AZM in the treatment of chronic pulmonary infections caused by P. aeruginosa. The aim of this review is to combine results from laboratory studies with evidence from clinical trials in order to unify the information on the in vivo mode of action of AZM in P. aeruginosa infection.
Document type :
Journal articles
Complete list of metadatas

Cited literature [66 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01181964
Contributor : Istituto Pasteur Fondazione Cenci Bolognetti <>
Submitted on : Thursday, July 30, 2015 - 12:27:58 PM
Last modification on : Wednesday, October 14, 2020 - 4:11:55 AM
Long-term archiving on: : Saturday, October 31, 2015 - 10:32:33 AM

File

fmicb-05-00178.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Francesco Imperi, Livia Leoni, Paolo Visca. Antivirulence activity of azithromycin in Pseudomonas aeruginosa.. Frontiers in microbiology, Frontiers Research Foundation, 2014, 5, pp.178. ⟨10.3389/fmicb.2014.00178⟩. ⟨pasteur-01181964⟩

Share

Metrics

Record views

157

Files downloads

478