Interleukin-1 and neuronal injury, Nature Reviews Immunology, vol.23, issue.8, pp.629-640, 1038. ,
DOI : 10.1016/S0304-3940(98)00537-0
Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory ???Barrel??? cortex, Glia, vol.60, issue.10, pp.1582-1594, 2013. ,
DOI : 10.1002/glia.22503
Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats, Neurobiology of Aging, vol.32, issue.11, pp.2030-2044, 2011. ,
DOI : 10.1016/j.neurobiolaging.2009.11.022
Fractalkine/CX3CL1 depresses central synaptic transmission in mouse hippocampal slices, Neuropharmacology, vol.51, issue.4, 2006. ,
DOI : 10.1016/j.neuropharm.2006.05.027
Regulation of Tau Pathology by the Microglial Fractalkine Receptor, Neuron, vol.68, issue.1, pp.19-31, 2010. ,
DOI : 10.1016/j.neuron.2010.08.023
TGF-?? signaling regulates neuronal C1q expression and developmental synaptic refinement, Nature Neuroscience, vol.127, issue.12, pp.1773-1782, 2013. ,
DOI : 10.1017/S0952523805225154
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973738
Neuronal ???On??? and ???Off??? signals control microglia, Trends in Neurosciences, vol.30, issue.11, 2007. ,
DOI : 10.1016/j.tins.2007.08.007
What is microglia neurotoxicity (Not)?, Glia, vol.41, issue.3-4, pp.841-854, 2014. ,
DOI : 10.1002/glia.22654
CX3CR1 deficiency exacerbates neuronal loss and impairs early regenerative responses in the target-ablated olfactory epithelium, Molecular and Cellular Neuroscience, vol.48, issue.3, pp.236-245, 2011. ,
DOI : 10.1016/j.mcn.2011.08.004
Adenosine signaling and function in glial cells, Cell Death and Differentiation, vol.939, issue.7, pp.1071-1082, 2010. ,
DOI : 10.1074/jbc.272.30.18518
Control of microglial neurotoxicity by the fractalkine receptor, Nature Neuroscience, vol.24, issue.7, pp.917-924, 1715. ,
DOI : 10.1038/nn1715
CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease, Journal of Biological Chemistry, vol.286, issue.37, pp.32713-32722, 2011. ,
DOI : 10.1074/jbc.M111.254268
Heme oxygenase???1 and carbon monoxide suppress autoimmune neuroinflammation, Journal of Clinical Investigation, vol.117, issue.2, pp.438-447, 1172. ,
DOI : 10.1172/JCI28844DS1
CX3CL1 Is Neuroprotective in Permanent Focal Cerebral Ischemia in Rodents, Journal of Neuroscience, vol.31, issue.45, pp.16327-16335, 2011. ,
DOI : 10.1523/JNEUROSCI.3611-11.2011
Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice, Journal of Neuroscience Research, vol.20, issue.Suppl 1, pp.1143-1151, 2013. ,
DOI : 10.1002/jnr.23242
ATP mediates rapid microglial response to local brain injury in vivo, Nature Neuroscience, vol.19, issue.6, pp.752-758, 1038. ,
DOI : 10.1523/JNEUROSCI.2294-04.2004
Atypical Antiinflammatory Activation of Microglia Induced by Apoptotic Neurons: Possible Role of Phosphatidylserine???Phosphatidylserine Receptor Interaction, Molecular Neurobiology, vol.29, issue.2, pp.197-212, 2004. ,
DOI : 10.1385/MN:29:2:197
Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse, Journal of Cerebral Blood Flow & Metabolism, vol.26, issue.10, pp.1707-172164, 2008. ,
DOI : 10.1016/S0165-5728(99)00202-7
Higher Plasma Fractalkine Is Associated With Better 6-Month Outcome From Ischemic Stroke, Stroke, vol.43, issue.9, pp.2300-2306, 2012. ,
DOI : 10.1161/STROKEAHA.112.657411
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance, Nature, vol.127, issue.7261, pp.282-286, 1983. ,
DOI : 10.1038/nature08296
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease, Nature Neuroscience, vol.20, issue.4, pp.411-413, 2010. ,
DOI : 10.1038/nn.2511
MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons, Journal of Neuroimmune Pharmacology, vol.677, issue.4, pp.246-256, 2008. ,
DOI : 10.1007/s11481-008-9118-2
Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation, The Journal of Immunology, vol.191, issue.3, pp.1063-1072, 2013. ,
DOI : 10.4049/jimmunol.1300040
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages, Science, vol.330, issue.6005, pp.841-845, 2010. ,
DOI : 10.1126/science.1194637
Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia, Proceedings of the National Academy of Sciences, vol.95, issue.18, pp.10896-10901, 1998. ,
DOI : 10.1073/pnas.95.18.10896
Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex, Journal of Neuroscience, vol.32, issue.43, pp.15106-15111, 2012. ,
DOI : 10.1523/JNEUROSCI.1167-12.2012
In vivo structure/function and expression analysis of the CX3C chemokine fractalkine, Blood, vol.118, issue.22, pp.156-167, 2011. ,
DOI : 10.1182/blood-2011-04-348946
Chemokines Promote Quiescence and Survival of Human Neural Progenitor Cells, Stem Cells, vol.22, issue.1, pp.22-23, 2004. ,
DOI : 10.1634/stemcells.22-1-109
Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation, J. Neurosci, vol.16, pp.2027-2033, 1996. ,
Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis, Brain, vol.137, issue.1, pp.78-91, 2014. ,
DOI : 10.1093/brain/awt323
Activity of Adenosine Receptors Type 1 Is Required for CX3CL1-Mediated Neuroprotection and Neuromodulation in Hippocampal Neurons, The Journal of Immunology, vol.180, issue.11, pp.7590-7596, 2008. ,
DOI : 10.4049/jimmunol.180.11.7590
CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models, The American Journal of Pathology, vol.177, issue.5, pp.2549-2562, 2010. ,
DOI : 10.2353/ajpath.2010.100265
Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia, Journal of Neuroimmunology, vol.160, issue.1-2, pp.92-101, 2005. ,
DOI : 10.1016/j.jneuroim.2004.11.012
Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity, Journal of Neuroimmunology, vol.166, issue.1-2, pp.19-28, 2005. ,
DOI : 10.1016/j.jneuroim.2005.03.023
CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-?? Phagocytosis, Journal of Neuroscience, vol.30, issue.50, pp.17091-17101, 2010. ,
DOI : 10.1523/JNEUROSCI.4403-10.2010
CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment, Front Cell Neurosci, 2011. ,
LTP impairment by fractalkine/CX3CL1 in mouse hippocampus is mediated through the activity of adenosine receptor type 3 (A3R), Journal of Neuroimmunology, vol.215, issue.1-2, pp.36-42, 2009. ,
DOI : 10.1016/j.jneuroim.2009.07.016
Macrophage Polarization Comes of Age, Immunity, vol.23, issue.4, pp.344-346, 2005. ,
DOI : 10.1016/j.immuni.2005.10.001
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival, Proc. Natl, 2000. ,
DOI : 10.1073/pnas.090017497
Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis, Journal of Neuroinflammation, vol.71, issue.1, pp.193-203, 2012. ,
DOI : 10.1186/1742-2094-9-193
CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis, Proceedings of the National Academy of Sciences, vol.105, issue.27, pp.9325-9330, 2008. ,
DOI : 10.1073/pnas.0711175105
Production and neuroprotective functions of fractalkine in the central nervous system, Brain Research, vol.979, issue.1-2, pp.65-70, 2003. ,
DOI : 10.1016/S0006-8993(03)02867-1
The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood, The Journal of Immunology, vol.188, issue.1, pp.29-36, 2012. ,
DOI : 10.4049/jimmunol.1100421
The Soluble Isoform of CX3CL1 Is Necessary for Neuroprotection in a Mouse Model of Parkinson's Disease, Journal of Neuroscience, vol.32, issue.42, pp.14592-146010539, 2012. ,
DOI : 10.1523/JNEUROSCI.0539-12.2012
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy, Neurobiology of Aging, vol.34, issue.6, pp.1540-1548, 2013. ,
DOI : 10.1016/j.neurobiolaging.2012.12.011
Phagocytosis executes delayed neuronal death after focal brain ischemia, Proceedings of the National Academy of Sciences, vol.110, issue.43, pp.4098-4107, 2013. ,
DOI : 10.1073/pnas.1308679110
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808587
Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death, The Journal of Immunology, vol.186, issue.8, pp.4973-4983, 2011. ,
DOI : 10.4049/jimmunol.1003600
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo, Science, vol.308, issue.5726, pp.1314-1318, 2005. ,
DOI : 10.1126/science.1110647
Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression, Journal of Biological Chemistry, vol.286, issue.3, pp.2308-2319, 2011. ,
DOI : 10.1074/jbc.M110.169839
Identification of a microglia phenotype supportive of remyelination, Glia, vol.25, issue.Part 4, pp.306-321, 2012. ,
DOI : 10.1002/glia.21266
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease, Journal of Neuroinflammation, vol.8, issue.1, pp.9-10, 2011. ,
DOI : 10.1186/1742-2094-8-9
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development, Science, vol.333, issue.6048, pp.1456-1458, 2011. ,
DOI : 10.1126/science.1202529
Evidence for a Gender-Specific Protective Role of Innate Immune Receptors in a Model of Perinatal Brain Injury, Journal of Neuroscience, vol.33, issue.28, pp.11556-11572, 2013. ,
DOI : 10.1523/JNEUROSCI.0535-13.2013
CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells, Journal of Neuroscience, vol.27, issue.40, pp.10714-10721, 2007. ,
DOI : 10.1523/JNEUROSCI.1922-07.2007
MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS, Glia, vol.185, issue.1, pp.91-103, 2013. ,
DOI : 10.1002/glia.22363
Chemokine Fractalkine/CX3CL1 Negatively Modulates Active Glutamatergic Synapses in Rat Hippocampal Neurons, Journal of Neuroscience, vol.26, issue.41, pp.10488-10498, 2006. ,
DOI : 10.1523/JNEUROSCI.3192-06.2006
Innate immunity in the central nervous system, Journal of Clinical Investigation, vol.122, issue.4, pp.1164-1171, 2012. ,
DOI : 10.1172/JCI58644
CX3CR1 Deficiency Leads to Impairment of Hippocampal Cognitive Function and Synaptic Plasticity, Journal of Neuroscience, vol.31, issue.45, pp.16241-162503667, 2011. ,
DOI : 10.1523/JNEUROSCI.3667-11.2011
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner, Neuron, vol.74, issue.4, pp.691-705, 2012. ,
DOI : 10.1016/j.neuron.2012.03.026
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells, Science, vol.336, issue.6077, pp.86-90, 2012. ,
DOI : 10.1126/science.1219179
Fractalkine (CX3CL1) enhances hippocampal N-methyl-Daspartate receptor (NMDAR) function via D-serine and adenosine receptor type A2 (A2AR) activity, J. Neuroinflammation, vol.10, pp.108-118, 2013. ,
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis, Frontiers in Cellular Neuroscience, vol.7, pp.1-22, 2013. ,
DOI : 10.3389/fncel.2013.00006
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis, Cell Stem Cell, vol.7, issue.4, pp.483-495, 2010. ,
DOI : 10.1016/j.stem.2010.08.014
URL : http://doi.org/10.1016/j.stem.2010.08.014
Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury, Journal of Neuroimmunology, vol.125, issue.1-2, pp.59-65, 2002. ,
DOI : 10.1016/S0165-5728(02)00033-4
Therapeutic Potential of Mesenchymal Stromal Cells and MSC Conditioned Medium in Amyotrophic Lateral Sclerosis (ALS) - In Vitro Evidence from Primary Motor Neuron Cultures, NSC-34 Cells, Astrocytes and Microglia, PLoS ONE, vol.69, issue.9, 2013. ,
DOI : 10.1371/journal.pone.0072926.g007
Microglial Interactions with Synapses Are Modulated by Visual Experience, PLoS Biology, vol.27, issue.Pt 17, 2010. ,
DOI : 10.1371/journal.pbio.1000527.s021
Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging, Journal of Neuroscience, vol.32, issue.19, pp.6435-6443, 2012. ,
DOI : 10.1523/JNEUROSCI.5925-11.2012
Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system, Hippocampus, vol.29, issue.325, pp.65-78, 2014. ,
DOI : 10.1002/hipo.22204
Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency, Neurobiology of Aging, vol.34, issue.12, pp.2843-2852, 2013. ,
DOI : 10.1016/j.neurobiolaging.2013.06.003
Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge, Brain, Behavior, and Immunity, vol.24, issue.7, pp.1190-1201, 2010. ,
DOI : 10.1016/j.bbi.2010.05.011
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation, Immunity, vol.40, issue.2, pp.274-288, 2014. ,
DOI : 10.1016/j.immuni.2014.01.006
Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior, Nature Neuroscience, vol.19, issue.3, pp.400-406, 2014. ,
DOI : 10.1006/cbmr.1996.0014
Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation, 4<305:: AID-GLIA2>3.0.CO, pp.305-3151098, 2000. ,
In vivo neutralization of endogenous brain fractalkine increases hippocampal TNF?? and 8-isoprostane production induced by intracerebroventricular injection of LPS, Journal of Neuroimmunology, vol.115, issue.1-2, pp.135-143, 2001. ,
DOI : 10.1016/S0165-5728(01)00259-4