Skip to Main content Skip to Navigation
Journal articles

Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique.

Abstract : The zoonosis bovine tuberculosis (TB) is known to be responsible for a considerable proportion of extrapulmonary TB. In Mozambique, bovine TB is a recognised problem in cattle, but little has been done to evaluate how Mycobacterium bovis has contributed to human TB. We here explore the public health risk for bovine TB in Maputo, by characterizing the isolates from tuberculous lymphadenitis (TBLN) cases, a common manifestation of bovine TB in humans, in the Pathology Service of Maputo Central Hospital, in Mozambique, during one year. Among 110 patients suspected of having TBLN, 49 had a positive culture result. Of those, 48 (98%) were positive for Mycobacterium tuberculosis complex and one for nontuberculous mycobacteria. Of the 45 isolates analysed by spoligotyping and Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR), all were M. tuberculosis. No M. bovis was found. Cervical TBLN, corresponding to 39 (86.7%) cases, was the main cause of TBLN and 66.7% of those where from HIV positive patients. We found that TBLN in Maputo was caused by a variety of M. tuberculosis strains. The most prevalent lineage was the EAI (n = 19; 43.2%). Particular common spoligotypes were SIT 48 (EAI1_SOM sublineage), SIT 42 (LAM 9), SIT 1 (Beijing) and SIT53 (T1), similar to findings among pulmonary cases. M. tuberculosis was the main etiological agent of TBLN in Maputo. M. tuberculosis genotypes were similar to the ones causing pulmonary TB, suggesting that in Maputo, cases of TBLN arise from the same source as pulmonary TB, rather than from an external zoonotic source. Further research is needed on other forms of extrapulmonary TB and in rural areas where there is high prevalence of bovine TB in cattle, to evaluate the risk of transmission of M. bovis from cattle to humans.
Document type :
Journal articles
Complete list of metadatas

Cited literature [53 references]  Display  Hide  Download

https://hal-riip.archives-ouvertes.fr/pasteur-01305143
Contributor : Nalin Rastogi <>
Submitted on : Wednesday, April 20, 2016 - 5:08:21 PM
Last modification on : Tuesday, October 20, 2020 - 10:49:28 AM
Long-term archiving on: : Thursday, July 21, 2016 - 3:52:04 PM

File

BMC_Micro2015-MOZ-w-Suppl.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Sofia Omar Viegas, Solomon Ghebremichael, Leguesse Massawo, Matos Alberto, Fabíola Couto Fernandes, et al.. Mycobacterium tuberculosis causing tuberculous lymphadenitis in Maputo, Mozambique.. BMC Microbiology, BioMed Central, 2015, 15, pp.268. ⟨10.1186/s12866-015-0603-5⟩. ⟨pasteur-01305143⟩

Share

Metrics

Record views

177

Files downloads

345