Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects.

Xavier Dagenais-Lussier 1 Aounallah Mouna 1 Jean-Pierre Routy 2 Cecile Tremblay 3, 4 Rafick-Pierre Sekaly 5, 6 Mohamed El-Far 7, 3 Julien Van Grevenynghe 1
1 INRS-IAF - Institut Armand Frappier
2 MUHC - McGill University Health Center [Montreal]
3 Centre de recherche
4 Department of Medicine, University of Montreal
5 VGTI - Vaccine and Gene Therapy Institute Florida
6 Case Western Reserve University [Cleveland]
7 Department of Microbiology, Infectiology and Immunology, Université de Montréal
Abstract : HIV-1 infection results in long-lasting activation of the immune system including elevated production of pro-inflammatory cytokine/chemokines, and bacterial product release from gut into blood and tissue compartments, which are not fully restored by antiretroviral therapies. HIV-1 has also developed numerous strategies via viral regulatory proteins to hijack cell molecular mechanisms to enhance its own replication and dissemination. Here, we reviewed the relationship between viral proteins, immune activation/inflammation, and deregulated metabolism occurring in HIV-1-infected patients that ultimately dampens the protective innate and adaptive arms of immunity. Defining precisely the molecular mechanisms related to deregulated immuno-metabolism during HIV-1 infection could ultimately help in the development of novel clinical approaches to restore proper immune functions in these patients.
Keywords : Inflammation Innate/adaptive immunity HIV-1 Immuno-metabolism
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Journal articles
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Contributor : Michel Courcelles <>
Submitted on : Tuesday, August 2, 2016 - 4:05:09 PM
Last modification on : Wednesday, December 19, 2018 - 11:56:03 AM

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Xavier Dagenais-Lussier, Aounallah Mouna, Jean-Pierre Routy, Cecile Tremblay, Rafick-Pierre Sekaly, et al.. Current topics in HIV-1 pathogenesis: The emergence of deregulated immuno-metabolism in HIV-infected subjects.. Cytokine & Growth Factor Reviews, 2015, 26 (6), pp.603-13. ⟨10.1016/j.cytogfr.2015.09.001 ⟩. ⟨pasteur-01351071⟩

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