No role for human papillomavirus infection in oral cancers in a region in southern India.

Claudie Laprise 1, 2 Sreenath A Madathil 3, 2 Paul Allison 1, 2 Priya Abraham 4 Anantharam Raghavendran 4 Hameed P Shahul 2 Akhil-Soman Thekkepurakkal 2 Geneviève Castonguay 2 François Coutlée 5 Nicolas F Schlecht 6 Marie-Claude Rousseau 2, 3 Eduardo L Franco 1, 2 Belinda Nicolau 1, 2
1 Division of Cancer Epidemiology
2 Division of Oral Health and Society
3 INRS-IAF - Institut Armand Frappier
4 Department of Clinical Virology, Christian Medical College
5 Hôpital Notre-Dame Du Centre De Recherche Du Centre Hospitalier De L'université De Montréal
6 ALBERT EINSTEIN COLLEGE OF MEDICINE - Albert Einstein College of Medicine
Abstract : Oral cancer is a major public health issue in India with ∼ 77,000 new cases and 52,000 deaths yearly. Paan chewing, tobacco and alcohol use are strong risk factors for this cancer in India. Human papillomaviruses (HPVs) are also related to a subset of head and neck cancers (HNCs). We examined the association between oral HPV and oral cancer in a sample of Indian subjects participating in a hospital-based case-control study. We recruited incident oral cancer cases (N = 350) and controls frequency-matched by age and sex (N = 371) from two main referral hospitals in Kerala, South India. Sociodemographic and behavioral data were collected by interviews. Epithelial cells were sampled using Oral CDx® brushes from the oral cancer site and the normal mucosa. Detection and genotyping of 36 HPV genotypes were done using a polymerase chain reaction protocol. Data collection procedures were performed by qualified dentists via a detailed protocol with strict quality control, including independent HPV testing in India and Canada. HPV DNA was detected in none of the cases or controls. Associations between oral cancer and risk factors usually associated with HPV infection, such as oral sex and number of lifetime sexual partners, were examined by logistic regression and were not associated with oral cancer. Lack of a role for HPV infection in this study may reflect cultural or religious characteristics specific to this region in India that are not conducive to oral HPV transmission. A nationwide representative prevalence study is needed to investigate HPV prevalence variability among Indian regions.
Keywords : HPV India human papillomavirus oral cancer oral squamous cell carcinoma
Type de document :
Article dans une revue
International Journal of Cancer, Wiley, 2016, 138 (4), pp.912-7. 〈10.1002/ijc.29827 〉
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https://hal-riip.archives-ouvertes.fr/pasteur-01351367
Contributeur : Michel Courcelles <>
Soumis le : mercredi 3 août 2016 - 15:34:44
Dernière modification le : lundi 8 octobre 2018 - 17:44:05

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Claudie Laprise, Sreenath A Madathil, Paul Allison, Priya Abraham, Anantharam Raghavendran, et al.. No role for human papillomavirus infection in oral cancers in a region in southern India.. International Journal of Cancer, Wiley, 2016, 138 (4), pp.912-7. 〈10.1002/ijc.29827 〉. 〈pasteur-01351367〉

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