Ozone treatment prevents the toxicity of an environmental mixture of estrogens on rat fetal testicular development.

Abstract : Effluents from wastewater treatment plants contain a mixture of estrogens (MIX: 17β-estradiol: E2, estrone: E1, estriol: E3 and 17α-ethinylestradiol EE2). High doses of estrogens have been shown to negatively impact fetal testicular development, but the impact of low doses of estrogens in mixture have yet to be elucidated. Using an organ culture system in which embryonic 15.5 day-old rat testes were grown ex vivo, we showed that exposure to the MIX at environmentally relevant concentrations reduces testis growth. No effect was observed on testosterone secretion, but we quantified a significant decrease in the number of Sertoli cells and gonocytes because of higher rates of apoptosis. As ozone (O3) can be used as a disinfectant during wastewater treatment, we confirmed by HPLC-MS analysis that it removes the four parent compounds. Interestingly, the negative effects of the MIX were not observed when testes were exposed to the MIX treated with O3.
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Reproductive toxicology (Elmsford, N.Y.), 2015, 58, pp.85-92. 〈10.1016/j.reprotox.2015.09.001 〉
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Soumis le : mercredi 3 août 2016 - 15:47:29
Dernière modification le : lundi 5 février 2018 - 15:22:10

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Guylaine Lassonde, Deniz Nasuhoglu, Jun Feng Pan, Bintou Gaye, Viviane Yargeau, et al.. Ozone treatment prevents the toxicity of an environmental mixture of estrogens on rat fetal testicular development.. Reproductive toxicology (Elmsford, N.Y.), 2015, 58, pp.85-92. 〈10.1016/j.reprotox.2015.09.001 〉. 〈pasteur-01351377〉

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