Effect of polymer architecture on curcumin encapsulation and release from PEGylated polymer nanoparticles: Toward a drug delivery nano-platform to the CNS.

Jean-Michel Rabanel 1 Jimmy Faivre 1 Ghislain Djiokeng Paka 2 Charles Ramassamy 2 Patrice Hildgen 1 Xavier Banquy 1
1 Université de Montréal [Montréal]
2 INRS-IAF - Institut Armand Frappier
Abstract : We developed a nanoparticles (NPs) library from poly(ethylene glycol)-poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative stress affecting the CNS. We observed a sharp decrease in size between 15 and 20% w/w of PEG which corresponds to a transition from a large solid particle structure to a "micelle-like" or "polymer nano-aggregate" structure. Drug loading, loading efficacy and release kinetics were determined. The diffusion coefficients of curcumin in NPs were determined using a mathematical modeling. The higher diffusion was observed for solid particles compared to "polymer nano-aggregate" particles. NPs did not present any significant toxicity when tested in vitro on a neuronal cell line. Moreover, the ability of NPs carrying curcumin to prevent oxidative stress was evidenced and linked to polymer architecture and NPs organization. Our study showed the intimate relationship between the polymer architecture and the biophysical properties of the resulting NPs and sheds light on new approaches to design efficient NP-based drug carriers.
Keywords : Poly(ethylene glycol) Micelle-like Nanoaggregate Nanoparticle CNS Comb-polymer Curcumin Poly(lactic) ROS Toxicity
Type de document :
Article dans une revue
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 2015, 96, pp.409-20. 〈10.1016/j.ejpb.2015.09.004 〉
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Soumis le : mercredi 3 août 2016 - 21:51:15
Dernière modification le : lundi 5 février 2018 - 15:22:10

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Jean-Michel Rabanel, Jimmy Faivre, Ghislain Djiokeng Paka, Charles Ramassamy, Patrice Hildgen, et al.. Effect of polymer architecture on curcumin encapsulation and release from PEGylated polymer nanoparticles: Toward a drug delivery nano-platform to the CNS.. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V, 2015, 96, pp.409-20. 〈10.1016/j.ejpb.2015.09.004 〉. 〈pasteur-01351539〉

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