Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

Abstract : Prenatal maternal stress (PNMS) is associated with children neurodevelopmental disorders. Serotonin is a crucial hormone, produced and transported by the placenta, for fetal brain development. Stress is known to affect serotonin reuptake by the serotonin transporter (SERT). Placental type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) protects the fetus by converting cortisol into inactive cortisone. Excess cortisol such as in PNMS is linked with serotonin-related pathological conditions (e.g. preeclampsia, autism), but the effect of PNMS on the placental serotonin systemhas never been studied.
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Placenta, Elsevier, 2015, 36 (9), pp.A9. 〈10.1016/j.placenta.2015.07.213〉
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Soumis le : jeudi 4 août 2016 - 15:46:58
Dernière modification le : jeudi 20 septembre 2018 - 13:16:05

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Joey St-Pierre, David P Laplante, Guillaume Elgbeili, Suzanne King, Cathy Vaillancourt. Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner. Placenta, Elsevier, 2015, 36 (9), pp.A9. 〈10.1016/j.placenta.2015.07.213〉. 〈pasteur-01351712〉

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