Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

Abstract : Prenatal maternal stress (PNMS) is associated with children neurodevelopmental disorders. Serotonin is a crucial hormone, produced and transported by the placenta, for fetal brain development. Stress is known to affect serotonin reuptake by the serotonin transporter (SERT). Placental type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) protects the fetus by converting cortisol into inactive cortisone. Excess cortisol such as in PNMS is linked with serotonin-related pathological conditions (e.g. preeclampsia, autism), but the effect of PNMS on the placental serotonin systemhas never been studied.
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Submitted on : Thursday, August 4, 2016 - 3:46:58 PM
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Joey St-Pierre, David P Laplante, Guillaume Elgbeili, Suzanne King, Cathy Vaillancourt. Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner. Placenta, Elsevier, 2015, 36 (9), pp.A9. ⟨10.1016/j.placenta.2015.07.213⟩. ⟨pasteur-01351712⟩

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