Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

Joey St-Pierre; David P Laplante; Guillaume Elgbeili; Suzanne King; Cathy Vaillancourt

Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

Joey St-Pierre ^{1, 2} David P Laplante ³ Guillaume Elgbeili ³ Suzanne King ^{4, 3} Cathy Vaillancourt ^{1, 2}

1 INRS-IAF - Institut Armand Frappier

2 BioMed Research Centre [Montréal]

3 Douglas Institute of Research

4 Université McGill

Abstract : Prenatal maternal stress (PNMS) is associated with children neurodevelopmental disorders. Serotonin is a crucial hormone, produced and transported by the placenta, for fetal brain development. Stress is known to affect serotonin reuptake by the serotonin transporter (SERT). Placental type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) protects the fetus by converting cortisol into inactive cortisone. Excess cortisol such as in PNMS is linked with serotonin-related pathological conditions (e.g. preeclampsia, autism), but the effect of PNMS on the placental serotonin systemhas never been studied.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-01351712
Contributor : Michel Courcelles <>
Submitted on : Thursday, August 4, 2016 - 3:46:58 PM
Last modification on : Wednesday, August 14, 2019 - 1:58:02 PM

Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

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Prenatal maternal stress alters placental serotonin system in a foetal sex dependent manner

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