Leishmania survival in the macrophage: where the ends justify the means.

Abstract : Macrophages are cells of the immune system that mediate processes ranging from phagocytosis to tissue homeostasis. Leishmania has evolved ingenious ways to adapt to life in the macrophage. The GP63 metalloprotease, which disables key microbicidal pathways, has recently been found to disrupt processes ranging from antigen cross-presentation to nuclear pore dynamics. New studies have also revealed that Leishmania sabotages key metabolic and signaling pathways to fuel parasite growth. Leishmania has also been found to induce DNA methylation to turn off genes controlling microbicidal pathways. These novel findings highlight the multipronged attack employed by Leishmania to subvert macrophage function.
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Article dans une revue
Current Opinion in Microbiology, Elsevier, 2015, Host–microbe interactions: fungi/parasites/viruses, 26, pp.32-40. 〈10.1016/j.mib.2015.04.007 〉
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Soumis le : jeudi 4 août 2016 - 17:46:09
Dernière modification le : lundi 29 août 2016 - 12:47:50

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Guillermo Arango Duque, Albert Descoteaux. Leishmania survival in the macrophage: where the ends justify the means.. Current Opinion in Microbiology, Elsevier, 2015, Host–microbe interactions: fungi/parasites/viruses, 26, pp.32-40. 〈10.1016/j.mib.2015.04.007 〉. 〈pasteur-01351880〉

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