Leishmania survival in the macrophage: where the ends justify the means. - RIIP - Réseau International des Instituts Pasteur Accéder directement au contenu
Article Dans Une Revue Current Opinion in Microbiology Année : 2015

Leishmania survival in the macrophage: where the ends justify the means.

Résumé

Macrophages are cells of the immune system that mediate processes ranging from phagocytosis to tissue homeostasis. Leishmania has evolved ingenious ways to adapt to life in the macrophage. The GP63 metalloprotease, which disables key microbicidal pathways, has recently been found to disrupt processes ranging from antigen cross-presentation to nuclear pore dynamics. New studies have also revealed that Leishmania sabotages key metabolic and signaling pathways to fuel parasite growth. Leishmania has also been found to induce DNA methylation to turn off genes controlling microbicidal pathways. These novel findings highlight the multipronged attack employed by Leishmania to subvert macrophage function.
Fichier non déposé

Dates et versions

pasteur-01351880 , version 1 (04-08-2016)

Identifiants

Citer

Guillermo Arango Duque, Albert Descoteaux. Leishmania survival in the macrophage: where the ends justify the means.. Current Opinion in Microbiology, 2015, Host–microbe interactions: fungi/parasites/viruses, 26, pp.32-40. ⟨10.1016/j.mib.2015.04.007⟩. ⟨pasteur-01351880⟩

Collections

RIIP INRS-IAF
21 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More