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Lung cancer risk among bricklayers in a pooled analysis of case-control studies.

Dario Consonni 1 Sara de Matteis 2, 3 Angela C Pesatori 1, 2 Pier Alberto Bertazzi 1, 2 Ann C Olsson 4, 5 Hans Kromhout 6 Susan Peters 7, 6 Roel C H Vermeulen 6 Beate Pesch 8 Thomas Brüning 8 Benjamin Kendzia 8 Thomas Behrens 8 Isabelle Stücker 9 Florence Guida 9 Heinz-Erich Wichmann 10 Irene Brüske 10 Maria Teresa Landi 11 Neil E Caporaso 11 Per Gustavsson 5 Nils Plato 5 Lap Ah Tse 12 Ignatius Tak-Sun Yu 12 Karl-Heinz Jöckel 13 Wolfgang Ahrens 14, 15 Hermann Pohlabeln 14 Franco Merletti 16 Lorenzo Richiardi 16 Lorenzo Simonato 17 Francesco Forastiere 18 Jack Siemiatycki 19 Marie-Élise Parent 20 Adonina Tardón 21 Paolo Boffetta 22, 23 David Zaridze 24 Ying Chen 25, 26 John K Field 26 Andrea 'T Mannetje Neil Pearce 27 John Mclaughlin 28 Paul Demers 29 Jolanta Lissowska 30 Neonila Szeszenia-Dabrowska 31 Vladimir Bencko 32 Lenka Foretova 33 Vladimir Janout 34 Peter Rudnai 35 Eleonóra Fabiánová 36 Rodica Stanescu Dumitru 37 H Bas Bueno-De-Mesquita 38, 3 Joachim Schüz 4 Kurt Straif 4
Abstract : Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analyzed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study center, age, lifetime smoking history and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32-1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p < 0.001). The relative risk was higher for squamous (OR: 1.68, 95% CI: 1.42-1.98, 309 cases) and small cell carcinomas (OR: 1.78, 95% CI: 1.44-2.20, 140 cases), than for adenocarcinoma (OR: 1.17, 95% CI: 0.95-1.43, 150 cases) (p-homogeneity: 0.0007). ORs were still elevated after additional adjustment for education and in analyses using blue collar workers as referents. This study provided robust evidence of increased lung cancer risk in bricklayers. Although non-causal explanations cannot be completely ruled out, the association is plausible in view of the potential for exposure to several carcinogens, notably crystalline silica and to a lesser extent asbestos.
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Dario Consonni, Sara de Matteis, Angela C Pesatori, Pier Alberto Bertazzi, Ann C Olsson, et al.. Lung cancer risk among bricklayers in a pooled analysis of case-control studies.. International Journal of Cancer, Wiley, 2015, 136 (2), pp.360-71. ⟨10.1002/ijc.28986⟩. ⟨pasteur-01351908⟩

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