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The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling.

Wilhelm Engström 1 Philippa Darbre 2 Staffan Eriksson 1 Linda Gulliver 3 Tove Hultman 1 Michalis V Karamouzis 4 James E Klaunig 5 Rekha Mehta 6 Kim Moorwood 7 Thomas Sanderson 8 Hideko Sone 9 Pankaj Vadgama 10 Gerard Wagemaker 11 Andrew Ward 7 Neetu Singh 12 Fahd Al-Mulla 13 Rabeah Al-Temaimi 13 Amedeo Amedei 14 Anna Maria Colacci 15 Monica Vaccari 15 Chiara Mondello 16 a Ivana Scovassi 16 Jayadev Raju 6 Roslida A Hamid 17 Lorenzo Memeo 18 Stefano Forte 18 Rabindra Roy 19 Jordan Woodrick 19 Hosni K Salem 20 Elizabeth P Ryan 21 Dustin G Brown 22 William H Bisson 23 
Abstract : The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.
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Submitted on : Friday, August 5, 2016 - 3:48:05 PM
Last modification on : Tuesday, December 7, 2021 - 4:26:03 PM

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Wilhelm Engström, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, et al.. The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling.. Carcinogenesis, Oxford University Press (OUP), 2015, 36 (Suppl 1), pp.S38-60. ⟨10.1093/carcin/bgv030⟩. ⟨pasteur-01352134⟩



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