Melatonin regulates autophagy and inflammation in human trophoblastic cells

Lucas Sagrillo Fagundes (1) , Eugênia Maria (1) , Assunção Salustiano (1) , Philippe Wong Yen (1) , Cathy Vaillancourt (1)

1 INRS-IAF - Institut Armand Frappier

Melatonin is produced by and protects villous trophoblasts against hypoxia/reoxygenation (H/R)-induced oxidative stress and apoptosis. However, melatonin’s anti-inflammatory activity and induction of autophagy in villous trophoblasts under H/R have never been investigated.

Domains: Life Sciences [q-bio]

Lucas Sagrillo Fagundes, Eugênia Maria, Assunção Salustiano, Philippe Wong Yen, Cathy Vaillancourt. Melatonin regulates autophagy and inflammation in human trophoblastic cells. Placenta, 2015, 36 (9), pp.A51-A52. ⟨10.1016/j.placenta.2015.07.342⟩. ⟨pasteur-01352136⟩