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Journal articles
Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.
Luca Freschi
1
Julie Jeukens
1
Irena Kukavica-Ibrulj
1
Brian Boyle
1
Marie-Josée Dupont
1
Jérôme Laroche
1
Stéphane Larose
1
Halim Maaroufi
1
Joanne L Fothergill
2
Matthew Moore
2
Geoffrey L Winsor
3
Shawn D Aaron
4
Jean Barbeau
5
Scott C Bell
6
Jane L Burns
7
Miguel Camara
8
André Cantin
9
Steve J Charette
1, 10
Ken Dewar
11
Éric Déziel
12
Keith Grimwood
13
Robert E W Hancock
14
Joe J Harrison
15
Stephan Heeb
8
Lars Jelsbak
16
Baofeng Jia
17
Dervla T Kenna
18
Timothy J Kidd
19, 20
Jens Klockgether
21
Joseph S Lam
22
Iain L Lamont
23
Shawn Lewenza
15
Nick Loman
24
François Malouin
9
Jim Manos
25
Andrew G Mcarthur
17
Josie Mckeown
8
Julie Milot
26
Hardeep Naghra
8
Dao Nguyen
11
Sheldon K Pereira
17
Gabriel G Perron
27
Jean-Paul Pirnay
28
Paul B Rainey
29, 30
Simon Rousseau
11
Pedro M Santos
31
Anne Stephenson
32
Véronique Taylor
22
Jane F Turton
18
Nicholas Waglechner
17
Paul Williams
8
Sandra W Thrane
16
Gerard D Wright
17
Fiona S L Brinkman
3
Nicholas P Tucker
33
Burkhard Tümmler
21
Craig Winstanley
2
Roger C Levesque
1, *
*
Corresponding author
Marie-Josée Dupont 1
Author
Jérôme Laroche 1
Author
Stéphane Larose 1
Author
Halim Maaroufi 1
Author
Joanne L Fothergill 2
Author
Matthew Moore 2
Author
Geoffrey L Winsor 3
Author
Shawn D Aaron 4
Author
Keith Grimwood 13
Author
Robert E W Hancock 14
Author
Joe J Harrison 15
Author
Stephan Heeb 8
Author
Sheldon K Pereira 17
Author
Gabriel G Perron 27
Author
Jean-Paul Pirnay 28
Author
Paul B Rainey 29, 30
Author
Simon Rousseau 11
Author
Pedro M Santos 31
Author
Anne Stephenson 32
Author
Véronique Taylor 22
Author
Jane F Turton 18
Author
Nicholas Waglechner 17
Author
Paul Williams 8
Author
Sandra W Thrane 16
Author
Gerard D Wright 17
Author
Fiona S L Brinkman 3
Author
Nicholas P Tucker 33
Author
Burkhard Tümmler 21
Author
Craig Winstanley 2
Author
Roger C Levesque 1
Correspondent author
1
ULaval - Université Laval [Québec] (2325, rue de l'Université Québec G1V 0A6 - Canada)
2
University of Liverpool (Liverpool L69 3BX, United Kingdom
- United Kingdom)
3
SFU.ca - Simon Fraser University (8888 University Drive, Burnaby, B.C. Canada V5A 1S6 - Canada)
4
OHRI - Ottawa Hospital Research Institute [Ottawa] (1053 Carling Ave, Ottawa, ON K1Y 4E9 - Canada)
5
UdeM - Université de Montréal (2900 Boulevard Edouard-Montpetit, Montréal, QC H3T 1J4 - Canada)
6
QIMR Berghofer Medical Research Institute (300 Herston Rd, Brisbane City QLD 4006 - Australia)
7
University of Washington School of Medicine (France)
8
UON - University of Nottingham, UK (University of Nottingham
University Park
Nottingham
NG7 2RD - United Kingdom)
9
UdeS - Université de Sherbrooke (2500 boul. de l'Université, Sherbrooke, Québec J1K 2R1 - Canada)
10
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie (G1V4G5 Québec, QC, Canada - Canada)
- ULaval - Université Laval [Québec] (2325, rue de l'Université Québec G1V 0A6 - Canada)
11
McGill University = Université McGill [Montréal, Canada] (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
12
INRS-IAF - Institut Armand Frappier (531 boul. des Prairies Laval (Québec) H7V 1B7 - Canada)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
- INRS - Institut National de la Recherche Scientifique [Québec] (490 rue de la Couronne, Québec, QC G1K 9A9 - Canada)
13
Griffith University [Brisbane] (PO Box 3370
South Brisbane QLD 4101 - Australia)
14
UBC - University of British Columbia (Vancouver Campus, , 2329 West Mall, Vancouver, BC, V6T 1Z4 /
Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7 - Canada)
15
University of Calgary (2500 University Dr NW Calgary, Alberta, T2N 1N4 - Canada)
16
DTU - Technical University of Denmark [Lyngby] (Anker Engelunds Vej 1, Building 101A, 2800 Kgs. Lyngby - Denmark)
17
McMaster University [Hamilton, Ontario] (1280 Main Street West
Hamilton, Ontario L8S 4L8 - Canada)
18
Public Health England [London] (Wellington House , 133-155 Waterloo Road, London SE1 8UG - United Kingdom)
19
University of Queensland [Brisbane] (Brisbane, St Lucia, QLD 4072 - Australia)
20
QUB - Queen's University [Belfast] (University Road, Belfast, BT7 1NN, Northern Ireland, UK - Ireland)
21
Klinische Forschergruppe (Hannover D-30625 - Germany)
- Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie (France)
- MHH - Medizinische Hochschule Hannover (Carl-Neuberg-Straße 1, 30625 Hannover, - Germany)
22
University of Guelph (50 Stone Road Easr, Guelph, Ontario, N1G2W1 - Canada)
23
University of Otago [Dunedin, Nouvelle-Zélande] (362 Leith St, North Dunedin, Dunedin 9016, New-Zeland - New Zealand)
24
University of Birmingham [Birmingham] (Edgbaston
Birmingham B15 2TT - United Kingdom)
25
The University of Sydney (New South Wales 2006 - Australia)
26
IUCPQ - Institut Universitaire de Cardiologie et de Pneumologie de Québec (2725, chemin Sainte-Foy
Québec (Québec) Canada
G1V 4G5 - )
- ULaval - Université Laval [Québec] (2325, rue de l'Université Québec G1V 0A6 - Canada)
28
Queen Astrid Military Hospital [Brussels] (1120 Brussels - Belgium)
29
Max Planck Institute for Evolutionary Biology (August-Thienemann-Str. 2, 24306 Plön - Germany)
- Max-Planck-Gesellschaft (Jägerstrasse, 10-11, D-10117 Berlin - Germany)
30
Massey University (Palmerston North, Auckland (Albany), Wellington, New Zealand - New Zealand)
31
University of Minho [Braga] (Largo do Paço, 4704-553 Braga - Portugal)
32
St. Michael's Hospital (Toronto - Canada)
33
University of Strathclyde [Glasgow] (16 Richmond Street, Glasgow G1 1XQ, Scotland, UK - United Kingdom)
Abstract : The International Pseudomonas aeruginosa Consortium is sequencing over 1000 genomes and building an analysis pipeline for the study of Pseudomonas genome evolution, antibiotic resistance and virulence genes. Metadata, including genomic and phenotypic data for each isolate of the collection, are available through the International Pseudomonas Consortium Database (http://ipcd.ibis.ulaval.ca/). Here, we present our strategy and the results that emerged from the analysis of the first 389 genomes. With as yet unmatched resolution, our results confirm that P. aeruginosa strains can be divided into three major groups that are further divided into subgroups, some not previously reported in the literature. We also provide the first snapshot of P. aeruginosa strain diversity with respect to antibiotic resistance. Our approach will allow us to draw potential links between environmental strains and those implicated in human and animal infections, understand how patients become infected and how the infection evolves over time as well as identify prognostic markers for better evidence-based decisions on patient care.
Document type :
Journal articles
Complete list of metadata
https://hal-riip.archives-ouvertes.fr/pasteur-01352145
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, August 5, 2016 - 4:21:35 PM
Last modification on : Friday, March 12, 2021 - 9:50:05 AM
Long-term archiving on: : Sunday, November 6, 2016 - 11:30:20 AM
Contributor : Michel Courcelles Connect in order to contact the contributor
Submitted on : Friday, August 5, 2016 - 4:21:35 PM
Last modification on : Friday, March 12, 2021 - 9:50:05 AM
Long-term archiving on: : Sunday, November 6, 2016 - 11:30:20 AM
File
fmicb-06-01036.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-01352145, version 1
- DOI : 10.3389/fmicb.2015.01036
- PUBMED : 26483767
- PUBMEDCENTRAL : PMC4586430
Citation
Luca Freschi, Julie Jeukens, Irena Kukavica-Ibrulj, Brian Boyle, Marie-Josée Dupont, et al.. Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium.. Frontiers in Microbiology, Frontiers Media, 2015, 6, pp.1036. ⟨10.3389/fmicb.2015.01036⟩. ⟨pasteur-01352145⟩
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