A feto-placental co-culture model shows the complex disruptive effect of the antidepressant fluoxetine and its metabolite norfluoxetine on estrogen biosynthesis and serotonin transport

Laetitia Laurent 1, 2 Andrée-Anne Hudon Thibeault 2, 1 J. Thomas Sanderson 1, 2 Cathy Vaillancourt 1, 2
1 INRS-IAF - Institut Armand Frappier
2 BioMed Research Center
Abstract : Up to 6.2% of pregnant women undergo antidepressant treatment with selective serotonin-reuptake inhibitors (SSRIs). SSRIs, which act on the serotonin transporter (SERT), have been associated with adverse effects on pregnancy. However, the action of one of the most prescribed SSRIs, fluoxetine, on the endocrine function of the feto-placental unit and placental serotonin transport has never been studied. Using a co-culture of BeWo (human trophoblast-like) and H295R (human fetal-like adrenocortical) cells, we studied the effects of fluoxetine and its active metabolite norfluoxetine on feto-placental estrogen biosynthesis and serotonin transport.
Type de document :
Article dans une revue
Placenta, Elsevier, 2015, 36 (9), pp.A37. 〈10.1016/j.placenta.2015.07.297〉
Liste complète des métadonnées
https://hal-riip.archives-ouvertes.fr/pasteur-01352185
Contributeur : Michel Courcelles <>
Soumis le : vendredi 5 août 2016 - 18:12:30
Dernière modification le : lundi 5 février 2018 - 15:22:10

Identifiants

Collections

RIIP | INRS-IAF

Citation

Laetitia Laurent, Andrée-Anne Hudon Thibeault, J. Thomas Sanderson, Cathy Vaillancourt. A feto-placental co-culture model shows the complex disruptive effect of the antidepressant fluoxetine and its metabolite norfluoxetine on estrogen biosynthesis and serotonin transport. Placenta, Elsevier, 2015, 36 (9), pp.A37. 〈10.1016/j.placenta.2015.07.297〉. 〈pasteur-01352185〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

20

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD