Molecular epidemiology of coxsackievirus type B1

Ichrak Abdelkhalek 1 Mohamed Seghier 2 Ahlem Ben Yahia 3, 4 Henda Touzi 3, 4 Zina Meddeb 3, 4 Henda Triki 3, 4 Dorra Rezig 3, 4, *
* Auteur correspondant
1 Faculté des Sciences de Bizerte
2 Institut Pasteur d'Algérie
3 UTM - Université Tunis El Manar
4 Institut Pasteur de Tunis
Abstract : Coxsackievirus type B1 (CVB1) has emerged globally as the predominant enterovirus serotype and is associated with epidemics of meningitis and chronic diseases. In this report, the phylogeny of CVB1 was studied based on the VP1 sequences of 11 North African isolates and 81 published sequences. All CVB1 isolates segregated into four distinct genogroups and 10 genotypes. Most of the identified genotypes of circulating CVB1 strains appear to have a strict geographical specificity. The North African strains were of a single genotype and probably evolved distinctly. Using a relaxed molecular clock model and three different population models (constant population, exponential growth and Bayesian skyline demographic models) in coalescent analysis using the BEAST program, the substitution rate in CVB1 varied between 6.95 x 10(-3) and 7.37 x 10(-3) substitutions/site/year in the VP1 region. This study permits better identification of circulating CVB1, which has become one of the most predominant enterovirus serotypes in humans.
Keywords : Coxsackievirus type B1 Enteroviruses VP1 gene Phylogeny Coxsackievirus type B1 Phylogeny VP1 gene
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Article dans une revue
Archives of Virology, Springer Verlag, 2015, 160 (11), pp.2815-2821. 〈10.1007/s00705-015-2561-5〉
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Contributeur : Institut Pasteur Tunis <>
Soumis le : mardi 12 septembre 2017 - 11:48:57
Dernière modification le : lundi 5 février 2018 - 15:22:12

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Ichrak Abdelkhalek, Mohamed Seghier, Ahlem Ben Yahia, Henda Touzi, Zina Meddeb, et al.. Molecular epidemiology of coxsackievirus type B1. Archives of Virology, Springer Verlag, 2015, 160 (11), pp.2815-2821. 〈10.1007/s00705-015-2561-5〉. 〈pasteur-01375030〉

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