Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Brig. Essential Oil

Imen Touihri 1 Maher Boukhris 2 Naziha Marrakchi 3 José Luis 4 Belgacem Hanchi 5 Olfa Kallech-Ziri 6
1 Institut National de Recherche et d'Analyse Physico-chimique (INRAP-Tunisie)
2 Faculté des Sciences de Sfax [Sfax]
3 LR11IPT08 - Laboratoire des Venins et Biomolécules Thérapeutiques
4 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
5 Faculté des Sciences de Tunis
6 INRAP - Institut National de Recherche et d'Analyse Physico-Chimique
Abstract : Allium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. roseum var. grandiflorum Brig. bulbs collected in the North of Tunisia were investigated. Chemical characterization has shown methyl methanethiosulfinate as major sulphurous compounds. A. roseum bulbs essential oil provides interesting antiproliferative activity against two human colonic adenocarcinoma HT29 and CACO2 cell lines in dose-dependent manner with a half-maximal inhibition (IC50) of 4.64 mu g/mL and 8.22 mu g/mL respectively. The antioxidant activity, as determined by FRAP assay, was 285 mu mol equivalent Trolox/g of essential oil. The scavenging effect on DPPH radicals of essential oil was estimated as IC50 values at 156 mu g/mL. The inhibition of superoxide anion production in a model of cancer cell lines was significant for both lines HT29 and CACO2 with IC50 of 20.25 mu g/mL and 29.12 mu g/mL respectively. Allium roseum essential oil exhibited antibacterial and antifungal activities with a high effectiveness against Candida albicans given by an MIC value of 0.019 mg/mL. This biological effect appears to be related mainly to the presence of organosulfur compounds.
Keywords : antiproliferative activity chemical composition essential oil Allium roseum L. antimicrobial activity antioxydant activity
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Article dans une revue
Journal of oleo science, Japan Oil Chemists Society, 2015, 64 (8), pp.869-879. 〈10.5650/jos.ess15055〉
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Soumis le : mardi 12 septembre 2017 - 10:42:59
Dernière modification le : jeudi 22 mars 2018 - 11:30:08

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Imen Touihri, Maher Boukhris, Naziha Marrakchi, José Luis, Belgacem Hanchi, et al.. Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Brig. Essential Oil. Journal of oleo science, Japan Oil Chemists Society, 2015, 64 (8), pp.869-879. 〈10.5650/jos.ess15055〉. 〈pasteur-01375034〉

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