Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil.

Imen Touihri 1 Maher Boukhris 2 Naziha Marrakchi 3 José Luis 4 Belgacem Hanchi 5 Olfa Kallech-Ziri 1
1 INRAP - Institut National de Recherche et d'Analyse Physico-Chimique
2 Laboratoire des Biotechnologies Végétales Appliquées à l'Amélioration des Cultures (Sfax, Tunisie)
3 LR11IPT08 - Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules
4 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
5 Faculté des Sciences de Tunis
Abstract : Allium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. roseum var. grandiflorum Briq. bulbs collected in the North of Tunisia were investigated. Chemical characterization has shown methyl methanethiosulfinate as major sulphurous compounds. A. roseum bulbs essential oil provides interesting antiproliferative activity against two human colonic adenocarcinoma HT29 and CACO2 cell lines in dose-dependent manner with a half-maximal inhibition (IC50) of 4.64 µg/mL and 8.22 µg/mL respectively. The antioxidant activity, as determined by FRAP assay, was 285 µmol equivalent Trolox/g of essential oil. The scavenging effect on DPPH radicals of essential oil was estimated as IC50 values at 156 µg/mL. The inhibition of superoxide anion production in a model of cancer cell lines was significant for both lines HT29 and CACO2 with IC50 of 20.25 µg/mL and 29.12 µg/mL respectively. Allium roseum essential oil exhibited antibacterial and antifungal activities with a high effectiveness against Candida albicans given by an MIC value of 0.019 mg/mL. This biological effect appears to be related mainly to the presence of organosulfur compounds.
Keywords : antiproliferative activity essential oil chemical composition Allium roseum L. antioxydant activity antimicrobial activity
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Article dans une revue
Journal of oleo science, Japan Oil Chemists Society, 2015, 64 (8), pp.869 - 879. 〈10.5650/jos.ess15055〉
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Imen Touihri, Maher Boukhris, Naziha Marrakchi, José Luis, Belgacem Hanchi, et al.. Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil.. Journal of oleo science, Japan Oil Chemists Society, 2015, 64 (8), pp.869 - 879. 〈10.5650/jos.ess15055〉. 〈hal-01481581〉

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