Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.

Houda Benrahma (1) , Hicham Charoute (1, 2) , Khaled Lasram (3) , Redouane Boulouiz (1, 2) , Rym Kefi-Ben Atig , Malika Fakiri (2) , Hassan Rouba (1) , Sonia Abdelhak (3) , Abdelhamid Barakat (1)

1 Institut Pasteur du Maroc
2 Laboratoire Agroalimentaire et Santé [Settat]
3 LR11IPT05 - Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory

Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.

Keywords: Genetic susceptibility; IGF2BP2 rs4402960; CDKAL1 rs7756992; KCNJ11 rs5219; Morocco

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism

Houda Benrahma, Hicham Charoute, Khaled Lasram, Redouane Boulouiz, Rym Kefi-Ben Atig, et al.. Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.. Biochemical Genetics, 2014, 52 (9-10), pp.430-42. ⟨10.1007/s10528-014-9658-5⟩. ⟨pasteur-01375062⟩