Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.

Houda Benrahma 1 Hicham Charoute 1, 2 Khaled Lasram 3 Redouane Boulouiz 1, 2 Rym Kefi-Ben Atig Malika Fakiri 2 Hassan Rouba 1 Sonia Abdelhak 3 Abdelhamid Barakat 1, *
* Auteur correspondant
1 Institut Pasteur du Maroc
2 Faculté des Sciences Techniques de Settat, Laboratoire agroalimentaire et santé
3 LR11IPT05 - Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory
Abstract : Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case-control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case-control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
Keywords : Genetic susceptibility IGF2BP2 rs4402960 CDKAL1 rs7756992 KCNJ11 rs5219 Morocco
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Article dans une revue
Biochemical Genetics, Springer Verlag, 2014, 52 (9-10), pp.430-42. 〈10.1007/s10528-014-9658-5〉
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Contributeur : Institut Pasteur Tunis <>
Soumis le : dimanche 2 octobre 2016 - 20:03:05
Dernière modification le : lundi 8 octobre 2018 - 17:44:08

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Houda Benrahma, Hicham Charoute, Khaled Lasram, Redouane Boulouiz, Rym Kefi-Ben Atig, et al.. Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis.. Biochemical Genetics, Springer Verlag, 2014, 52 (9-10), pp.430-42. 〈10.1007/s10528-014-9658-5〉. 〈pasteur-01375062〉

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