Contribution of Specific Anti-Hydatid IgG Subclasses in the Diagnosis of Echinococcosis Primary Infection and Relapses

Meriem Benabid 1 Yousr Galai 2 Ramzi Nouira 3 Karim Aoun 1
1 LR11IPT06 - Laboratoire de Parasitologie Médicale, Biotechnologies et Biomolécules
2 Laboratoire d'immunologie clinique [Institut Pasteur de Tunis]
3 Hôpital Charles Nicolle
Résumé : Serological diagnosis of hydatid disease still faces problems of sensitivity, limiting its use to either diagnosis or post-surgical monitoring. The use of IgG subclasses seems to overcome these difficulties. The contribution of IgG subclasses was evaluated in the diagnosis of primary infested and hydatid cyst relapse patients. A group of patients (n = 34) diagnosed for the first time with liver cystic echinococcosis (CE) and a group of patients with CE surgical recurrence were included. Enzyme-linked immunosorbent assay anti-hydatid antigens (HA) specific IgG1, 2, 3, and 4 subclasses were analyzed by ROC curves. ROC curve analyses demonstrated that IgG4 had the ability to discriminate between primary infested and relapsed groups whereas IgG2 was not discriminatory. The sensitivity of IgG4 was statistically higher in the relapsed cases group (97.1% versus 70.6%, p = 0.008). anti-HA specific IgG2 was the best marker of primary infestation whereas IgG4 was the best marker of relapse.
Keywords : IgG subclasses ROC curve hydatid cyst
Type de document :
Article dans une revue
Clinical Laboratory, Clinical Laboratory Publications, 2013, 59 (3-4), pp.293-8. 〈10.7754/Clin.Lab.2012.120405〉
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https://hal-riip.archives-ouvertes.fr/pasteur-01375122
Contributeur : Institut Pasteur Tunis <>
Soumis le : lundi 4 septembre 2017 - 15:26:58
Dernière modification le : lundi 5 février 2018 - 15:22:12

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Meriem Benabid, Yousr Galai, Ramzi Nouira, Karim Aoun. Contribution of Specific Anti-Hydatid IgG Subclasses in the Diagnosis of Echinococcosis Primary Infection and Relapses. Clinical Laboratory, Clinical Laboratory Publications, 2013, 59 (3-4), pp.293-8. 〈10.7754/Clin.Lab.2012.120405〉. 〈pasteur-01375122〉

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