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HB S [beta 6(A3)GLU -> VAL, GAG > GTG] AND beta-GLOBIN GENE CLUSTER HAPLOTYPE DISTRIBUTION IN MAURITANIA

Fatimetou M. Veten 1 Isselmou O. Abdelhamid 2 Ghlana M. Meiloud 1 Sidi M. Ghaber 2 Mohamed L. Salem 2 Salem Abbes 3 Ahmed O. Houmeida 1
1 Faculté des Sciences et Techniques [Nouakchott, Mauritania]
2 Centre Hospitalier National, B.P. 4160, Nouakchott, Mauritania
3 LR11IPT07 - Laboratoire d'hématologie moléculaire et cellulaire
Abstract : Of 1050 Mauritanian blood donors screened from the two main racial groups, i.e., the Moors and Black Africans, 60 were found to carry Hb S [beta 6(A3) Glu -> Val, GAG>GTG], giving a global frequency of 5.71%. The prevalence observed in the Black African Mauritanians (10.69%) is almost five times that found in the Moor group (2.25%). Four of the five main beta(S) haplotypes were detected in this study: Senegal (77.8%), Benin (8.8%), Arab-Indian (5.5%) and Bantu (4.4%). These data showed that Hb S is a serious public health problem in Mauritania. They also confirm the ethnic heterogeneity of the Mauritanian population.
Keywords : Population Hb S Hemoglobin (Hb) Frequency Mauritania beta(S) Haplotypes
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Submitted on : Monday, September 4, 2017 - 11:54:35 AM
Last modification on : Wednesday, August 7, 2019 - 3:30:04 PM

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Fatimetou M. Veten, Isselmou O. Abdelhamid, Ghlana M. Meiloud, Sidi M. Ghaber, Mohamed L. Salem, et al.. HB S [beta 6(A3)GLU -> VAL, GAG > GTG] AND beta-GLOBIN GENE CLUSTER HAPLOTYPE DISTRIBUTION IN MAURITANIA. Hemoglobin, Informa Healthcare, 2012, 36 (4), pp.311-315. ⟨10.3109/03630269.2012.688782⟩. ⟨pasteur-01375140⟩

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