HB S [beta 6(A3)GLU -> VAL, GAG > GTG] AND beta-GLOBIN GENE CLUSTER HAPLOTYPE DISTRIBUTION IN MAURITANIA

Fatimetou M. Veten (1) , Isselmou O. Abdelhamid (2) , Ghlana M. Meiloud (1) , Sidi M. Ghaber (2) , Mohamed L. Salem (2) , Salem Abbes (3) , Ahmed O. Houmeida (1)

1 Faculté des Sciences et Techniques [Nouakchott, Mauritania]
2 Centre Hospitalier National, B.P. 4160, Nouakchott, Mauritania
3 LR11IPT07 - Laboratoire d'hématologie moléculaire et cellulaire

Of 1050 Mauritanian blood donors screened from the two main racial groups, i.e., the Moors and Black Africans, 60 were found to carry Hb S [beta 6(A3) Glu -> Val, GAG>GTG], giving a global frequency of 5.71%. The prevalence observed in the Black African Mauritanians (10.69%) is almost five times that found in the Moor group (2.25%). Four of the five main beta(S) haplotypes were detected in this study: Senegal (77.8%), Benin (8.8%), Arab-Indian (5.5%) and Bantu (4.4%). These data showed that Hb S is a serious public health problem in Mauritania. They also confirm the ethnic heterogeneity of the Mauritanian population.

Mots clés: Population; Hemoglobin (Hb); Frequency; Hb S; beta(S) Haplotypes; Mauritania

Domaines: Sciences du Vivant [q-bio]

Fatimetou M. Veten, Isselmou O. Abdelhamid, Ghlana M. Meiloud, Sidi M. Ghaber, Mohamed L. Salem, et al.. HB S [beta 6(A3)GLU -> VAL, GAG > GTG] AND beta-GLOBIN GENE CLUSTER HAPLOTYPE DISTRIBUTION IN MAURITANIA. Hemoglobin, 2012, 36 (4), pp.311-315. ⟨10.3109/03630269.2012.688782⟩. ⟨pasteur-01375140⟩