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Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.

Abstract : Envenomation by Hemiscorpius lepturus (H. lepturus) is associated with local necrosis, followed by systemic manifestations. In this work the LD₅₀ of H. lepturus venom were determined by subcutaneous (SC) injection in white Balb/c mice (5 mg/kg). Histopathological alterations in organs such as kidney, heart, liver, lungs, stomach and intestine were determined in 3, 6, 12 and 24 h following experimental (SC) envenoming injection of one LD ₅₀ of the venom in Balb/c mice. Histological studies showed degenerative changes in the kidney with disorganized glomeruli and necrotic tubular in 3 h and reached to its climax in 6 h. Myocardium showed massive myocytolysis with interstitial necrosis in 3 h and reached to its peak after 6 h past envenoming. Bowels showed edema of lamina propria and slight villous necrosis. The enzymatic activities of creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in the serum in 9 h. No necrotic lesion observed in lungs and liver. The results indicate that the venom of H. lepturus is a highly cytotoxic, and induces massive tissue damages in specific organs, starting from the heart and kidney as the first target in 3 h and ends to the bowels in 6 h post envenomation.
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Submitted on : Sunday, October 2, 2016 - 11:20:30 PM
Last modification on : Wednesday, September 23, 2020 - 10:48:02 AM

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Mojgan Heidarpour, Emna Ennaifer, Hamed Ahari, Najet Srairi-Abid, Lamia Borchani, et al.. Histopathological changes induced by Hemiscorpius lepturus scorpion venom in mice.. Toxicon, Elsevier, 2012, 59 (3), pp.373-8. ⟨10.1016/j.toxicon.2011.12.011⟩. ⟨pasteur-01375142⟩

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