Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.

Myriam Ammar 1, * Fatma Bouazizi 1 Rym Bouhaha 1 Ines Zaraa 2 Soumaya Kouidhi 1 Slah Ourheni 3 Cindy Helms 4 Nejib Doss 5 Raouf Dhaoui 5 Amel Ben Osman 2 Amel Ben Ammar-El Gaaïed 1 Raja Marrakchi 1 Mourad Mokni 2 Chiraz Bouchlaka-Souissi 1
* Corresponding author
1 Laboratory of Genetics, Immunology and Human Pathology
2 Service de dermatologie
3 Institut Pasteur de Tunis
4 Department of Human Genetics
5 Department of Dermatology
Abstract : An association between a common deletion comprising the late cornified envelope LCE3B and LCE3C genes (LCE3C_LCE3B-del) and psoriasis has been reported in Caucasian and Asian populations. To investigate whether this deletion plays a role in the genetic of psoriasis in Tunisian population, we determined the LCE3C_LCE3B-del genotype in 180 Ps patients and 208 healthy controls from different regions of Tunisia. The LCE3B and LCE3C gene variant was determined in the patients through PCR amplification and the SPSS software package. The frequency of the LCE3C_LCE3B-del was similar between patients and healthy controls. Subanalyses by family history revealed that the frequency of LCE3C_LCE3B-del was significantly higher in patients with a positive family history than in control individuals, as well as in individuals with a positive family history versus those without in the case cohort. However, no significant difference was observed between psoriatic patients with no family history and controls. We also evaluated the relationship between LCE3C_LCE3B-del and PSORS1. No significant epistatic effect was observed suggesting that there was no significant epistasis of the two loci in the Tunisian population. Our findings indicate that the LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population.
Keywords : CNV EDC deletion Association analysis Psoriasis
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Journal articles
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Contributor : Institut Pasteur Tunis <>
Submitted on : Sunday, October 2, 2016 - 11:20:33 PM
Last modification on : Tuesday, April 23, 2019 - 3:04:02 PM

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Myriam Ammar, Fatma Bouazizi, Rym Bouhaha, Ines Zaraa, Soumaya Kouidhi, et al.. Association analysis of LCE3C-LCE3B deletion in Tunisian psoriatic population.. Archives of Dermatological Research, Springer Verlag, 2012, 304 (9), pp.733-8. ⟨10.1007/s00403-012-1279-4⟩. ⟨pasteur-01375144⟩

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