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Neorogioltriol: A brominated diterpene with analgesic activity from Laurencia glandulifera

Abstract : The new tricyclic brominated diterpenoid, neorogioltriol (1), was isolated from the organic extract of the red alga Laurencia glandulifera, collected at Kefalonia Island in Western Greece. Assignment of the (1)H and (13)C NMR resonances were carried out by extensive analysis of its NMR spectra. The new metabolite was evaluated for its analgesic activity using the writhing test in mice and the formalin test in rats. A dose-dependant antiinociceptive response was observed in the writhing test at 0.5 and 1 mg/kg with an IC(50) of 12.5 mu g/kg. Compound 1 also inhibited the second phase of the formalin test. (c) 2008 Phytochemical Society of Europe Published by Elsevier B.V. All rights reserved.
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Rim Chatter, Maria Kladi, Safa Tarhouni, Riadh Maatoug, Riadh Kharrat, et al.. Neorogioltriol: A brominated diterpene with analgesic activity from Laurencia glandulifera. Phytochemistry Letters, Elsevier, 2009, 2 (1), pp.25-28. ⟨10.1016/j.phytol.2008.10.008⟩. ⟨pasteur-01375179⟩

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