Quantitative detection of bcr-abl transcripts in chronic myeloid leukemia

S. Menif 1 S. Zarrouki 1 R. Jeddi 2 N. Alaya 1, 2, 3, 4 Z. Belhadj Ali 2 H. Ben Abid 2 S. Hdeiji 4 M. Elloumi 4 A. Khlif 3 B. Meddeb 2 K. Dellagi 1
1 LR11IPT07 - Laboratoire d'hématologie moléculaire et cellulaire
2 hôpital Aziza Othmana, Serv Hematol
3 Hôpital Farhat Hached Sousse, Serv Hematol
4 Hop Hadi Chacker, Serv Hematol
Abstract : The optimal management of malignant haematological disorders depend on the degree of tumor load reduction after therapy. Chronic myeloid leukemia constitutes a clinical model for molecular detection and therapy surveillance of malignant disease since this entity was the first leukemia shown to be associated with a specific bcr-abl fusion gene in the patient's leukemia cells. Molecular monitoring of bcr-abl transcript levels by real-time quantitative PCR is increasingly used to assess treatment response in patients with chronic myeloid leukemia (CML). This has become particulary relevant in the era of imatinib therapy when residual levels of leukaemia usually fall below the level of detection by bone marrow cytogenetic analysis. We monitored bcr-abl transcript levels by quantitative real time PCR in 50 tunisian patients treated with imatinib for chronic myeloid leukemia in chronic phase for a median of 29 months (3-60) after they started imatinib. (C) 2008 Elsevier Masson SAS. All rights reserved.
Keywords : PCR Residual disease Chronic myeloid leukemia Imatinib RQ
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Pathologie Biologie, Elsevier Masson, 2009, 57 (5), pp.388-391. 〈10.1016/j.patbio.2007.12.010〉
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Contributeur : Institut Pasteur Tunis <>
Soumis le : mardi 6 décembre 2016 - 14:29:08
Dernière modification le : lundi 8 octobre 2018 - 17:44:07

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S. Menif, S. Zarrouki, R. Jeddi, N. Alaya, Z. Belhadj Ali, et al.. Quantitative detection of bcr-abl transcripts in chronic myeloid leukemia. Pathologie Biologie, Elsevier Masson, 2009, 57 (5), pp.388-391. 〈10.1016/j.patbio.2007.12.010〉. 〈pasteur-01375194〉

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