Leishmaniose endonasale primitive à Leishmania infantum MON-80 en Tunisie

R. Benmously-Mlika 1, * S. Fenniche 1 N. Kerkeni 1 K. Aoun 2 A. Khedim 3 I. Mokhtar 1
* Auteur correspondant
1 Department of Dermatology
2 Laboratoire de Parasitologie, Institut Pasteur de Tunis
3 Service d’otorhinolaryngologie
Abstract : Background. - Mucocutaneous leishmaniasis is endemic in Central and South America. It causes massive mutilating and disfiguring lesions and can lead to destruction of facial structures. In Tunisia, leishmaniasis of the mucous membranes is rare, usually developing as a complication of cutaneous leishmaniasis via direct extension. We report the first case in Tunisia of isolated and primary nasal leishmaniasis. Case report. - A 70-year-old man with a history of nephrectomy for renal lithiasis was seen with a painless nodule that had been present for one month. The latter was erythematous, polypoid and firm, with a diameter of 2 cm, and was situated in the right endonasal mucosa. The diagnosis of leishmaniasis was confirmed by histological and direct examinations revealing high numbers of amastigotes of Leishmania. Culture of the offending organism in NNN medium and isoenzymatic characterization resulted in identification of MON-80 Leishmania infantum leishmaniasis. The outcome was good with treatment, and the nodule was deflated after six months. Discussion. - There have been few reports of similar cases of primary and isolated mucosal leishmaniasis caused by Leishmania infantum. Our case is also unusual in that zymodeme MON80 is only rarely a cause of Mediterranean leishmaniasis. (c) 2008 Elsevier Masson SAS. Tous droits reserves.
Keywords : Leishmania infantum MON-80 endonasal leishmaniasis Tunisia
Type de document :
Article dans une revue
Annales de Dermatologie et de Vénéréologie, Elsevier Masson, 2008, 135 (5), pp.389 - 392. 〈10.1016/j.annder.2007.10.006〉
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Contributeur : Institut Pasteur Tunis <>
Soumis le : mercredi 14 décembre 2016 - 13:47:28
Dernière modification le : lundi 5 février 2018 - 15:22:12

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R. Benmously-Mlika, S. Fenniche, N. Kerkeni, K. Aoun, A. Khedim, et al.. Leishmaniose endonasale primitive à Leishmania infantum MON-80 en Tunisie. Annales de Dermatologie et de Vénéréologie, Elsevier Masson, 2008, 135 (5), pp.389 - 392. 〈10.1016/j.annder.2007.10.006〉. 〈pasteur-01375205〉

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