&. Possani and L. , A novel structural class of K + channel blocking toxin from the scorpion Pandinus imperator, Biochem J, vol.315, pp.977-981, 1996.

R. Kharrat, K. Mabrouk, M. Crest, H. Darbon, R. Oughideni et al., Chemical Synthesis and Characterization of Maurotoxin, a Short Scorpion Toxin with four Disulfide Bridges that Acts on K+ Channels, European Journal of Biochemistry, vol.33, issue.3, pp.491-498, 1996.
DOI : 10.1002/(SICI)1097-0134(199603)24:3<359::AID-PROT9>3.0.CO;2-B

F. Bontems, C. Roumestand, B. Gilquin, A. Menez, and F. Toma, Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins, Science, vol.254, issue.5037, pp.1521-1523, 1991.
DOI : 10.1126/science.1720574

J. Aiyar, J. Rizzi, G. Gutman, and K. Chandy, The Signature Sequence of Voltage-gated Potassium Channels Projects into the External Vestibule, Journal of Biological Chemistry, vol.271, issue.49, pp.31013-31016, 1996.
DOI : 10.1074/jbc.271.49.31013

J. Aiyar, J. Withka, J. Rizzi, D. Singleton, G. Andrews et al., Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins, Neuron, vol.15, issue.5, pp.1169-1181, 1995.
DOI : 10.1016/0896-6273(95)90104-3

P. Stampe, L. Kolmakova-partensky, and C. Miller, Intimations of potassium channel structure from a complete functional map of the molecular surface of charybdotoxin, Biochemistry, vol.33, issue.2, pp.443-450, 1994.
DOI : 10.1021/bi00168a008

C. Park and C. Miller, Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin, Biochemistry, vol.31, issue.34, pp.7749-7755, 1992.
DOI : 10.1021/bi00149a002

R. 16-ranganathan, J. Lewis, and R. Mackinnon, Spatial Localization of the K+ Channel Selectivity Filter by Mutant Cycle???Based Structure Analysis, Neuron, vol.16, issue.1, pp.131-139, 1996.
DOI : 10.1016/S0896-6273(00)80030-6

K. Giangiacomo, E. Sugg, M. Garcia-calvo, R. Leonard, O. Mcmanus et al., Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels, Biochemistry, vol.32, issue.9, pp.2363-2370, 1993.
DOI : 10.1021/bi00060a030

E. Blanc, J. Sabatier, R. Kharrat, S. Meunier, M. Ayeb et al., Solution structure of maurotoxin, a scorpion toxin from Scorpio maurus, with high affinity for voltage???gated potassium channels, Proteins: Structure, Function, and Genetics, vol.29, issue.3, pp.321-333, 1997.
DOI : 10.1002/(SICI)1097-0134(199711)29:3<321::AID-PROT6>3.3.CO;2-K

J. Guijarro, M. Barek, S. Go´mezgo´mez-lagunas, F. Garnier, D. Rochat et al., Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels, Protein Science, vol.239, issue.9, pp.1844-1854, 2003.
DOI : 10.1110/ps.03186703
URL : https://hal.archives-ouvertes.fr/pasteur-00364861

J. Tytgat, G. Chandy, M. Garcia, G. Gutman, M. Martin-eauclaire et al., A unified nomenclature for short-chain peptides isolated from scorpion venoms, 1999.

T. Olamendi-portugal, F. Gomez-langunas, G. Gurola, and L. Possani, Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels, Toxicon, vol.36, issue.5, pp.759-770, 1998.
DOI : 10.1016/S0041-0101(97)00163-3

B. 22-lebrun, R. Romi-lebrun, M. Martin-eauclaire, A. Yasuda, M. Ishiguro et al., A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom, Biochemical Journal, vol.328, issue.1, pp.321-327, 1997.
DOI : 10.1042/bj3280321

S. Zhu, I. Huy, K. Dayson, F. Verdonck, and J. Tytgat, Evolutionary trace analysis of scorpion toxins specific for K-channels, Proteins: Structure, Function, and Bioinformatics, vol.15, issue.16, pp.361-370, 2004.
DOI : 10.1002/prot.10588

N. Yamaji, L. Dai, K. Sugase, M. Andriantsiferana, T. Nakajima et al., Solution structure of IsTX, European Journal of Biochemistry, vol.7, issue.19, pp.3855-3864, 2004.
DOI : 10.1111/j.1432-1033.2004.04322.x

Y. Sugahara, S. Nirthanan, I. Huys, K. Kobayashi, T. Kohno et al., Synthesis and characterization of spinoxin, a novel peptide toxin from the Malaysian black scorpion, Peptide Science ? Proceedings of the 40th Symposium on Japanese Peptide Symposium (Ueki M, pp.283-284, 2004.

M. Bagda´nybagda´ny, C. Batista, N. Valdez-cruz, S. Somodi, . Rodriguez-de-la et al., Anuroctoxin, a New Scorpion Toxin of the ??-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes, Molecular Pharmacology, vol.67, issue.4, pp.1034-1044, 2005.
DOI : 10.1124/mol.104.007187

E. Schwartz, C. Schwartz, F. Go´mezgo´mez-lagunas, F. Zamudio, and L. Possani, HgeTx1, the first K+-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad, Toxicon, vol.48, issue.8, pp.1046-1053, 2006.
DOI : 10.1016/j.toxicon.2006.08.009

M. Soleglad and V. Fet, High-level systematics and phylogeny of the extant scorpions (Scorpiones: Orthosterni ), Euscorpius, vol.11, pp.1-175, 2003.

R. Kharrat, P. Mansuelle, F. Sampieri, M. Crest, R. Oughideni et al., venom: purification, structure and action on potassium channels, FEBS Letters, vol.390, issue.3, pp.284-290, 1997.
DOI : 10.1016/S0014-5793(97)00285-8

N. Castle, D. London, C. Creech, Z. Fajloun, J. Stocker et al., Maurotoxin: A Potent Inhibitor of Intermediate Conductance Ca2+-Activated Potassium Channels, Molecular Pharmacology, vol.63, issue.2, pp.409-418, 2003.
DOI : 10.1124/mol.63.2.409

M. Dauplais, A. Lecoq, J. Song, J. Cotton, N. Jamin et al., On the Convergent Evolution of Animal Toxins: CONSERVATION OF A DIAD OF FUNCTIONAL RESIDUES IN POTASSIUM CHANNEL-BLOCKING TOXINS WITH UNRELATED STRUCTURES, Journal of Biological Chemistry, vol.272, issue.7, pp.4302-4309, 1997.
DOI : 10.1074/jbc.272.7.4302

Z. Fajloun, A. Mosbah, E. Carlier, P. Mansuelle, G. Sandoz et al., Maurotoxin Versus Pi1/HsTx1 Scorpion Toxins: TOWARD NEW INSIGHTS IN THE UNDERSTANDING OF THEIR DISTINCT DISULFIDE BRIDGE PATTERNS, Journal of Biological Chemistry, vol.275, issue.50, pp.39394-39402, 2000.
DOI : 10.1074/jbc.M006810200

S. Jones and J. Thornton, Analysis of protein-protein interaction sites using surface patches, Journal of Molecular Biology, vol.272, issue.1, pp.121-132, 1997.
DOI : 10.1006/jmbi.1997.1234

S. Goldstein, D. Pheasant, and C. Miller, The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition, Neuron, vol.12, issue.6, pp.1377-1388, 1994.
DOI : 10.1016/0896-6273(94)90452-9

M. Bednarek, B. Johnson, S. Stevens, R. Bugianesi, J. Felix et al., SAR of margatoxin, a potent and selective inhibitor of voltage-activated potassium channel Kv1.3 in human T-cell lymphocytes, In Peptides: Chemistry, Structure and Biology, 1996.

V. Visan, Z. Fajloun, J. Sabatier, and S. Grissmer, Mapping of Maurotoxin Binding Sites on hKv1.2, hKv1.3, and hIKCa1 Channels, Molecular Pharmacology, vol.66, issue.5, pp.1103-1112, 2004.
DOI : 10.1124/mol.104.002774

W. Fu, M. Cui, J. Briggs, X. Huang, B. Xiong et al., Brownian Dynamics Simulations of the Recognition of the Scorpion Toxin Maurotoxin with the Voltage-Gated Potassium Ion Channels, Biophysical Journal, vol.83, issue.5, pp.2370-2385, 2002.
DOI : 10.1016/S0006-3495(02)75251-X

P. Savarin, R. Romi-lebrun, S. Zinn-justin, B. Lebrun, T. Nakajima et al., Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: Solution structure of the potassium channel inhibitor HsTX1, Protein Science, vol.320, issue.12, pp.2672-2685, 1999.
DOI : 10.1110/ps.8.12.2672

M. Bradford, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Analytical Biochemistry, vol.72, issue.1-2, pp.248-254, 1976.
DOI : 10.1016/0003-2697(76)90527-3

N. Galeotti, A. Bartolini, and C. Ghelardini, Diphenhydramine-induced amnesia is mediated by Gi-protein activation, Neuroscience, vol.122, issue.2, pp.471-478, 2003.
DOI : 10.1016/j.neuroscience.2003.08.005

E. Gray and V. Whittaker, The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization centrifugation, J Anat, vol.96, pp.79-88, 1962.

M. Swift, GraphPad Prism, Data Analysis, and Scientific Graphing, Journal of Chemical Information and Computer Sciences, vol.37, issue.2, pp.411-412, 1997.
DOI : 10.1021/ci960402j

E. Soto, E. Salceda, R. Cruz, A. Ortega, and R. Vega, Microcomputer program for automated action potential waveform analysis, Computer Methods and Programs in Biomedicine, vol.62, issue.2, pp.141-144, 2000.
DOI : 10.1016/S0169-2607(00)00053-5

N. Srairi-abid, Purification, characterization and molecular modelling of two toxin-like proteins from the Androctonus australis Hector venom, European Journal of Biochemistry, vol.23, issue.17, pp.4641-4650, 2000.
DOI : 10.1046/j.1432-1327.2000.01632.x
URL : https://hal.archives-ouvertes.fr/pasteur-00877296

P. Edman and G. Begg, A Protein Sequenator, European Journal of Biochemistry, vol.4, issue.1, pp.80-91, 1967.
DOI : 10.1111/j.1432-1033.1967.tb00047.x

A. Savitzky and M. Golay, Smoothing and Differentiation of Data by Simplified Least Squares Procedures., Analytical Chemistry, vol.36, issue.8, pp.1627-1639, 1964.
DOI : 10.1021/ac60214a047

S. Altschul, T. Madden, A. Schaffer, J. Zhang, Z. Zhang et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

A. Sali and T. Blundell, Comparative protein modeling by satisfaction of spatial restraints, Acta Crystallographica Section A Foundations of Crystallography, vol.52, issue.a1, pp.779-815, 1993.
DOI : 10.1107/S0108767396095578

E. Abola, N. Manning, J. Prilusky, D. Stampf, and J. Sussman, The Protein Data Bank: Current status and future challenges, Journal of Research of the National Institute of Standards and Technology, vol.101, issue.3, pp.231-241, 1996.
DOI : 10.6028/jres.101.025

G. Kleywegt and T. Jones, Phi/Psi-chology: Ramachandran revisited, Structure, vol.4, issue.12, pp.1395-1400, 1996.
DOI : 10.1016/S0969-2126(96)00147-5
URL : http://doi.org/10.1016/s0969-2126(96)00147-5

S. Tosatto, The Victor/FRST Function for Model Quality Estimation, Journal of Computational Biology, vol.12, issue.10, pp.1316-1327, 2005.
DOI : 10.1089/cmb.2005.12.1316