Healing of old world cutaneous leishmaniasis in travelers treated with fluconazole: Drug effect or spontaneous evolution?

Gloria Morizot 1 Pascal Delgiudice 2 Eric Caumes 3 Emmanuel Laffitte 4 Pierre Marty 5 Alain Dupuy 3 Claudine Sarfati 3 Smain Hadj-Rabia 3 Herve Darie 1 Anne-Sophie Le Guern 1 Afif Ben Salah 6 Francine Pratlong 7 Jean-Pierre Dedet 7 Max Grögl 8 Pierre A. Buffet 1, *
* Auteur correspondant
1 CRVBm - Centre de Recherche Vaccinale et Biomédicale
2 Centre Hospitalier Intercommunal de Fréjus - St Raphaël
3 Assistance publique - Hôpitaux de Paris - AP-HP (FRANCE)
4 CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne]
5 CHU de Nice - Centre Hospitalier Universitaire de Nice
6 Laboratoire d'Epidémiologie et d'Ecologie parasitaire, Institut Pasteur de Tunis
7 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle
8 Tripler Army Medical Center
Abstract : The efficacy of fluconazole was evaluated in 35 travelers with parasitologically proven imported Old World cutaneous leishmaniasis (CL). Leishmania major (mainly MON-25) was identified in 15 patients and strongly suspected given the transmission area in 12 of these patients. Daily oral fluconazole (200 mg/day for adults and 2.5 mg/kg/day for children) was prescribed for six weeks. Outcome definition was based on re-epithelialization rate at day 50. Of the 27 L. major-infected patients, 12 (44.4%) were cured. This cure rate is similar to the placebo cure rate from trials in L. major CL in which, as in the present report, the definition of outcome relied exclusively on re-epithelialization. These data question the assumption that oral fluconazole is consistently effective for treatment of CL caused by L. major.
Type de document :
Article dans une revue
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2007, 76 (1), pp.48-52. 〈10.4269/ajtmh.2007.76.48〉
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Contributeur : Institut Pasteur Tunis <>
Soumis le : lundi 3 octobre 2016 - 01:55:31
Dernière modification le : vendredi 19 octobre 2018 - 09:41:38

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Gloria Morizot, Pascal Delgiudice, Eric Caumes, Emmanuel Laffitte, Pierre Marty, et al.. Healing of old world cutaneous leishmaniasis in travelers treated with fluconazole: Drug effect or spontaneous evolution?. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2007, 76 (1), pp.48-52. 〈10.4269/ajtmh.2007.76.48〉. 〈pasteur-01375238〉

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