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Journal articles
Healing of old world cutaneous leishmaniasis in travelers treated with fluconazole: Drug effect or spontaneous evolution?
Gloria Morizot
1
Pascal Delgiudice
2
Eric Caumes
3
Emmanuel Laffitte
4
Pierre Marty
5
Alain Dupuy
3
Claudine Sarfati
3
Smain Hadj-Rabia
3
Herve Darie
1
Anne-Sophie Le Guern
1
Afif Ben Salah
6
Francine Pratlong
7
Jean-Pierre Dedet
7
Max Grögl
8
Pierre A. Buffet
1, *
*
Corresponding author
Herve Darie 1
Author
Anne-Sophie Le Guern 1
Author
Afif Ben Salah 6
Author
Francine Pratlong 7
Author
1
CRVBm - Centre de Recherche Vaccinale et Biomédicale (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
2
Centre Hospitalier Intercommunal de Fréjus - St Raphaël (CHI de Fréjus - St Raphaël Service de Radiodiagnostic, BP 110, 83608 Fréjus Cedex - France)
- CHI Fréjus - St Raphaël - Centre Hospitalier Intercommunal Fréjus - St Raphaël (240 Avenue de Saint-Lambert, 83600 Fréjus - France)
4
CHUV - Centre Hospitalier Universitaire Vaudois [Lausanne] (Rue du Bugnon 21
CH-1011 Lausanne, Vaud - Switzerland)
6
Laboratoire d'Epidémiologie et d'Ecologie parasitaire, Institut Pasteur de Tunis (Tunisia)
- Institut Pasteur de Tunis (13, place Pasteur, BP 74, 1002 Tunis Belvédère - Tunisia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
7
MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (911 Avenue Agropolis BP 64501 34394 Montpellier cedex 5 - France)
- UM - Université de Montpellier : UMR5290 (163 rue Auguste Broussonnet - 34090 Montpellier - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5290 (France)
- IRD [France-Sud] - Institut de Recherche pour le Développement : 224 (911 avenue Agropolis, BP 64501 34394 Montpellier cedex 5 - France)
8
Tripler Army Medical Center (Honolulu, HI 96859 - United States)
Abstract : The efficacy of fluconazole was evaluated in 35 travelers with parasitologically proven imported Old World cutaneous leishmaniasis (CL). Leishmania major (mainly MON-25) was identified in 15 patients and strongly suspected given the transmission area in 12 of these patients. Daily oral fluconazole (200 mg/day for adults and 2.5 mg/kg/day for children) was prescribed for six weeks. Outcome definition was based on re-epithelialization rate at day 50. Of the 27 L. major-infected patients, 12 (44.4%) were cured. This cure rate is similar to the placebo cure rate from trials in L. major CL in which, as in the present report, the definition of outcome relied exclusively on re-epithelialization. These data question the assumption that oral fluconazole is consistently effective for treatment of CL caused by L. major.
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Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-01375238
Contributor : Institut Pasteur Tunis <>
Submitted on : Monday, October 3, 2016 - 1:55:31 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:14 AM
Contributor : Institut Pasteur Tunis <>
Submitted on : Monday, October 3, 2016 - 1:55:31 AM
Last modification on : Wednesday, August 19, 2020 - 11:18:14 AM
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- HAL Id : pasteur-01375238, version 1
- PUBMED : 17255228
- DOI : 10.4269/ajtmh.2007.76.48
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RIIP | CNRS | RIIP_TUNIS | PASTEUR | UNIV-MONTPELLIER | AGROPOLIS | B3ESTE
Citation
Gloria Morizot, Pascal Delgiudice, Eric Caumes, Emmanuel Laffitte, Pierre Marty, et al.. Healing of old world cutaneous leishmaniasis in travelers treated with fluconazole: Drug effect or spontaneous evolution?. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2007, 76 (1), pp.48-52. ⟨10.4269/ajtmh.2007.76.48⟩. ⟨pasteur-01375238⟩
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