F. S. Markland, Snake venoms and the hemostatic system, Toxicon, vol.36, issue.12, pp.1749-1800, 1998.
DOI : 10.1016/S0041-0101(98)00126-3

A. Ménez, Perspectives in Molecular Toxinology, 2002.

P. Juárez, L. Sanz, and J. J. Calvete, Snake venomics: Characterization of protein families inSistrurus barbouri venom by cysteine mapping,N-terminal sequencing, and tandem mass spectrometry analysis, PROTEOMICS, vol.4, issue.2, pp.327-338, 2004.
DOI : 10.1002/pmic.200300628

J. White, Snake venoms and coagulopathy, Toxicon, vol.45, issue.8, pp.951-967, 2005.
DOI : 10.1016/j.toxicon.2005.02.030

A. M. Moura-da-silva, R. D. Theakston, and J. M. Crampton, Evolution of disintegrin cysteine-rich and mammalian matrix-degrading metalloproteinases: Gene duplication and divergence of a common ancestor rather than convergent evolution, Journal of Molecular Evolution, vol.2, issue.15, pp.263-269, 1996.
DOI : 10.1007/BF02338834

B. G. Fry and W. Wüster, Assembling an Arsenal: Origin and Evolution of the Snake Venom Proteome Inferred from Phylogenetic Analysis of Toxin Sequences, Molecular Biology and Evolution, vol.21, issue.5, pp.870-883, 2004.
DOI : 10.1093/molbev/msh091

B. G. Fry, From genome to "venome": Molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins, Genome Research, vol.15, issue.3, pp.403-420, 2005.
DOI : 10.1101/gr.3228405

J. J. Calvete, C. Marcinkiewicz, D. Monleón, V. Esteve, B. Celda et al., Snake venom disintegrins: evolution of structure and function, Toxicon, vol.45, issue.8, pp.1063-1074, 2005.
DOI : 10.1016/j.toxicon.2005.02.024

J. J. Calvete, Structure-Function Correlations of Snake Venom Disintegrins&#, Current Pharmaceutical Design, vol.11, issue.7, pp.829-835, 2005.
DOI : 10.2174/1381612053381783

R. Kini and H. J. Evans, Structural domains in venom proteins: Evidence that metalloproteinases and nonenzymatic platelet aggregation inhibitors (disintegrins) from snake venoms are derived by proteolysis from a common precursor, Toxicon, vol.30, issue.3, pp.265-293, 1992.
DOI : 10.1016/0041-0101(92)90869-7

K. Shimokawa, L. Jai, X. Wang, and J. W. Fox, Expression, Activation, and Processing of the Recombinant Snake Venom Metalloproteinase, Pro-Atrolysin E, Archives of Biochemistry and Biophysics, vol.335, issue.2, pp.283-294, 1996.
DOI : 10.1006/abbi.1996.0509

J. J. Calvete, M. P. Moreno-murciano, R. D. Theakston, D. G. Kisiel, and C. Marcinkiewicz, Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering, Biochemical Journal, vol.372, issue.3, pp.725-734, 2003.
DOI : 10.1042/bj20021739

J. J. Calvete, M. Jürgens, C. Marcinkiewicz, A. Romero, M. Schrader et al., Disulphide-bond pattern and molecular modelling of the dimeric disintegrin EMF-10, a potent and selective integrin ??5??1 antagonist from Eristocophis macmahoni venom, Biochemical Journal, vol.345, issue.3, pp.573-581, 2000.
DOI : 10.1042/bj3450573

S. Bilgrami, S. Tomar, S. Yadav, P. Kaur, J. Kumar et al., Crystal Structure of Schistatin, a Disintegrin Homodimer from Saw-scaled Viper (Echis carinatus) at 2.5?? Resolution, Journal of Molecular Biology, vol.341, issue.3, pp.829-837, 2004.
DOI : 10.1016/j.jmb.2004.06.048

A. Bazaa, N. Marrakchi, M. Ayeb, L. Sanz, and J. J. Calvete, Snake venomics: Comparative analysis of the venom proteomes of the Tunisian snakesCerastes cerastes, Cerastes vipera andMacrovipera lebetina, PROTEOMICS, vol.379, issue.16, pp.4223-4235, 2005.
DOI : 10.1002/pmic.200402024

R. A. Harrison, J. Oliver, S. S. Hasson, K. Bharati, and R. D. Theakston, Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species, Gene, vol.315, pp.95-102, 2003.
DOI : 10.1016/S0378-1119(03)00716-9

L. Blanc, J. C. Hager, J. W. Ilisiu, A. M. Hunter, C. Zhong et al., Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (Q TRAP) used for high sensitivity proteomics applications, PROTEOMICS, vol.3, issue.6, pp.859-869, 2003.
DOI : 10.1002/pmic.200300415

O. Kallech-ziri, J. Luis, S. Daoud, A. Bazaa, N. Srairi et al., Lebestatin, a short disintegrin from Macrovipera lebetina venom, inhibits integrin-mediated adhesion, migration of tumor cells and in vivo angiogenesis, Lab. Invest, vol.85, pp.1507-1516, 2005.

C. Marcinkiewicz, P. H. Wainreb, J. J. Calvete, D. G. Kisiel, S. A. Mousa et al., Obtustatin: a potent selective inhibitor of ? 1 ? 1 integrin in vitro and angiogenesis in vivo, Cancer Res, vol.63, pp.2020-2023, 2003.

P. Moreno-murciano, D. Monleón, J. J. Calvete, B. Celda, and C. Marcinkiewicz, Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa, Protein Science, vol.12, issue.2, pp.366-371, 2003.
DOI : 10.1110/ps.0230203

D. G. Kisiel, J. J. Calvete, J. Katzhendel, A. Fertala, P. Lazarovici et al., Structural determinants of the selectivity of KTS-disintegrins for the ??1??1 integrin, FEBS Letters, vol.274, issue.3, pp.478-482, 2004.
DOI : 10.1016/j.febslet.2004.10.050

M. P. Moreno-murciano, D. Monleón, C. Marcinkiewicz, J. J. Calvete, and B. Celda, NMR Solution Structure of the Non-RGD Disintegrin Obtustatin, Journal of Molecular Biology, vol.329, issue.1, pp.135-145, 2003.
DOI : 10.1016/S0022-2836(03)00371-1

D. Monleón, M. P. Moreno-murciano, H. Kovacs, C. Marcinkiewicz, J. J. Calvete et al., Concerted Motions of the Integrin-binding Loop and the C-terminal Tail of the Non-RGD Disintegrin Obtustatin, Journal of Biological Chemistry, vol.278, issue.46, pp.45570-45576, 2003.
DOI : 10.1074/jbc.M307030200

L. Sanz, R. Chen, A. Pérez, R. Hilario, P. Juárez et al., Integrin, Journal of Biological Chemistry, vol.280, issue.49, pp.40714-40722, 2005.
DOI : 10.1074/jbc.M509738200

I. M. Francischetti, V. My-pham, J. Harrison, M. K. Garfield, and J. M. Ribeiro, Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins, Gene, vol.337, pp.55-69, 2004.
DOI : 10.1016/j.gene.2004.03.024

A. Gasmi, N. Srairi, S. Guermazi, H. Dkhil, H. Karoui et al., Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1547, issue.1, pp.51-56, 2001.
DOI : 10.1016/S0167-4838(01)00168-6

J. A. Eble, P. Bruckner, and U. Mayer, Vipera lebetina Venom Contains Two Disintegrins Inhibiting Laminin-binding ??1 Integrins, Journal of Biological Chemistry, vol.278, issue.29, pp.26488-26496, 2003.
DOI : 10.1074/jbc.M301860200

E. Siigur, A. Aaspollu, A. T. Tu, and J. Siigur, cDNA Cloning and Deduced Amino Acid Sequence of Fibrinolytic Enzyme (Lebetase) fromVipera lebetinaSnake Venom, Biochemical and Biophysical Research Communications, vol.224, issue.1, pp.229-236, 1996.
DOI : 10.1006/bbrc.1996.1012

S. Bilgrami, S. Yadav, S. Sharma, M. Perbandt, C. Betzel et al., ) at 1.9 ?? Resolution, Biochemistry, vol.44, issue.33, pp.11058-11066, 2005.
DOI : 10.1021/bi050849y

T. Ogawa, T. Chijiwa, N. Oda-ueda, and M. Ohno, Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom, Toxicon, vol.45, issue.1, pp.1-14, 2005.
DOI : 10.1016/j.toxicon.2004.07.028

J. Xiong, T. Stehle, R. Zhang, A. Joachimiak, M. Frech et al., Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3 in Complex with an Arg-Gly-Asp Ligand, Science, vol.296, issue.5565, pp.151-155, 2002.
DOI : 10.1126/science.1069040

A. L. Hughes, Evolution of the Integrin ?? and ?? Protein Families, Journal of Molecular Evolution, vol.52, issue.1, pp.63-72, 2001.
DOI : 10.1007/s002390010134

R. O. Hynes, Integrins, Cell, vol.110, issue.6, pp.673-687, 2002.
DOI : 10.1016/S0092-8674(02)00971-6

R. Ewan, J. Huxley-jones, A. P. Mould, M. J. Humphries, D. L. Robertson et al., The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family, BMC Evolutionary Biology, vol.5, issue.1, p.31, 2005.
DOI : 10.1186/1471-2148-5-31

M. Huhtala, J. Heino, D. Casciari, A. De-luise, and M. S. Johnson, Integrin evolution: Insights from ascidian and teleost fish genomes, Matrix Biology, vol.24, issue.2, pp.83-95, 2005.
DOI : 10.1016/j.matbio.2005.01.003