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In vivo evidence for the resistance of Theileria annulata to buparvaquone.

Abstract : The present study describes an outbreak of tropical theileriosis cases refractory to buparvaquone treatment, which occurred in a small-size dairy farm in Tunisia. Out of seven treated cows, four died in spite of repeated buparvaquone injections (2.5 and 5 mg kg(-1)) and the monitoring of the affected cows showed no improvement of the course of the disease with a consistent decrease in the haematocrit, the persistence of fever and an increased parasitaemia after treatment. Ticks were fed on a calf experimentally infected with one isolate established in culture from one of the cases and the resultant infected ticks ground up to generate a supernatant infected with the potentially resistant stock. This was used to experimentally infect three calves, and the clinical observations, post-buparvaquone treatment, showed an absence of the usual effect of buparvaquone treatment on the parasite Theileria annulata, such as the rapid decline of schizont index and parasitaemia and a rapid recovery from the disease. These results confirmed for the first time the occurrence of resistance to buparvaquone in the protozoan T. annulata.
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Submitted on : Wednesday, December 21, 2016 - 11:23:40 AM
Last modification on : Wednesday, October 28, 2020 - 3:24:11 PM




Moez Mhadhbi, Abdelkarim Naouach, Aïssa Boumiza, Mohamed Faouzi Chaabani, Souha Benabderazzak, et al.. In vivo evidence for the resistance of Theileria annulata to buparvaquone.. Veterinary Parasitology, Elsevier, 2010, 169 (3-4), pp.241-7. ⟨10.1016/j.vetpar.2010.01.013⟩. ⟨pasteur-01375290⟩



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