HLA class II alleles and multiple sclerosis in Tunisian patients

Amira Messadi; Fekih-Mrissa Najiba; Slah Ouerhani; Jemel Zaweli; Ines Louatti; Sami Layouni; Brahim Nciri; Ghaya Bouaicha; Wafa Kouki; Mondher Yedeas; Aly Raies; Ridha Mrissa; Nasreddine Gritli

HLA class II alleles and multiple sclerosis in Tunisian patients

Amira Messadi ^{1, *} Fekih-Mrissa Najiba ¹ Slah Ouerhani ² Jemel Zaweli ³ Ines Louatti ³ Sami Layouni ¹ Brahim Nciri ¹ Ghaya Bouaicha ¹ Wafa Kouki ¹ Mondher Yedeas ⁴ Aly Raies ⁵ Ridha Mrissa ³ Nasreddine Gritli ¹

* Corresponding author

1 Department of Hematology

2 Institut Pasteur de Tunis

3 Department of Neurology

4 Department of Neurosurgery

5 Laboratory of Micro-organisms and Active Bio-molecules

Abstract : Objective The aim of our study was to investigate the association of HLA-DRB1 and -DQB1 alleles with multiple sclerosis (MS) in a Tunisian population and their effect on age at onset and disease severity Methods 58 MS patients and 105 healthy controls were genotyped for HLA class II alleles by PCR-SSP technique Results An association of MS with HLA-DRB1*15 was found (147% vs 3 8%, OR (95% CI) = 4 34 (1 69-11 39) P(c) = 2 5 x 10(-3)) after Bonferroni's correction Moreover the DRB1*15-DQB1*06 (138% vs 28%, OR (95% CI) = 5 44 (1 92-17 41) p(c) = 1 1 x 10(-3)) and DRB1*04-DQB1*04 (86% vs 19% OR (95% CI)- 4 86 (1 36-21 62) p(c) = 0 028) haplotypes were found to confer a susceptibility to multiple sclerosis Conclusion To our knowledge this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on MS susceptibility in Tunisia The modern Tunisian gene pool shows some degree of heterogeneity and reflects a significant gene flow from Mediterranean regions (C) 2010 Elsevier B V All rights reserved

Keywords : PCR-SSP HLA class II polymorphism Multiple sclerosis Case-control study

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-01375307
Contributor : Institut Pasteur Tunis <>
Submitted on : Wednesday, January 4, 2017 - 9:23:03 AM
Last modification on : Monday, October 8, 2018 - 5:44:08 PM

HLA class II alleles and multiple sclerosis in Tunisian patients

Identifiers

Collections

Citation

Export

Metrics

106

Contact

HLA class II alleles and multiple sclerosis in Tunisian patients

Identifiers

Collections

Citation

Export

Share

Metrics

106

Contact