HLA class II alleles and multiple sclerosis in Tunisian patients

Amira Messadi 1, * Fekih-Mrissa Najiba 1 Slah Ouerhani 2 Jemel Zaweli 3 Ines Louatti 3 Sami Layouni 1 Brahim Nciri 1 Ghaya Bouaicha 1 Wafa Kouki 1 Mondher Yedeas 4 Aly Raies 5 Ridha Mrissa 3 Nasreddine Gritli 1
* Corresponding author
1 Department of Hematology
2 Institut Pasteur de Tunis
3 Department of Neurology
4 Department of Neurosurgery
5 Laboratory of Micro-organisms and Active Bio-molecules
Abstract : Objective The aim of our study was to investigate the association of HLA-DRB1 and -DQB1 alleles with multiple sclerosis (MS) in a Tunisian population and their effect on age at onset and disease severity Methods 58 MS patients and 105 healthy controls were genotyped for HLA class II alleles by PCR-SSP technique Results An association of MS with HLA-DRB1*15 was found (147% vs 3 8%, OR (95% CI) = 4 34 (1 69-11 39) P(c) = 2 5 x 10(-3)) after Bonferroni's correction Moreover the DRB1*15-DQB1*06 (138% vs 28%, OR (95% CI) = 5 44 (1 92-17 41) p(c) = 1 1 x 10(-3)) and DRB1*04-DQB1*04 (86% vs 19% OR (95% CI)- 4 86 (1 36-21 62) p(c) = 0 028) haplotypes were found to confer a susceptibility to multiple sclerosis Conclusion To our knowledge this is the first study performed to analyze the association of HLA-DRB1/DQB1 alleles on MS susceptibility in Tunisia The modern Tunisian gene pool shows some degree of heterogeneity and reflects a significant gene flow from Mediterranean regions (C) 2010 Elsevier B V All rights reserved
Keywords : PCR-SSP HLA class II polymorphism Multiple sclerosis Case-control study
Document type :
Journal articles
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https://hal-riip.archives-ouvertes.fr/pasteur-01375307
Contributor : Institut Pasteur Tunis <>
Submitted on : Wednesday, January 4, 2017 - 9:23:03 AM
Last modification on : Monday, October 8, 2018 - 5:44:08 PM

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Amira Messadi, Fekih-Mrissa Najiba, Slah Ouerhani, Jemel Zaweli, Ines Louatti, et al.. HLA class II alleles and multiple sclerosis in Tunisian patients. Clinical Neurology and Neurosurgery, Elsevier, 2010, 112 (10), pp.849 - 852. ⟨10.1016/j.clineuro.2010.07.004⟩. ⟨pasteur-01375307⟩

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