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Journal articles
The impact of smoking and polymorphic enzymes of xenobiotic metabolism on the stage of bladder tumors: a generalized ordered logistic regression analysis
Abstract : Cigarette smoking is the predominant risk factor for bladder cancer in males and females. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes such as N-acetyltransferases (NAT) and glutathione S-transferases (GST). Polymorphisms in NAT and GST genes alter the ability of these enzymes to metabolize carcinogens. In this paper, we conduct a statistical analysis based on logistic regressions to assess the impact of smoking and metabolizing enzyme genotypes on the risk to develop bladder cancer using a case-control study from Tunisia. We also use the generalized ordered logistic model to investigate whether these factors do have an impact on the progression of bladder tumors.
https://hal-riip.archives-ouvertes.fr/pasteur-01375312
Contributor : Institut Pasteur Tunis <>
Submitted on : Monday, October 3, 2016 - 2:34:27 AM
Last modification on : Friday, October 23, 2020 - 9:22:31 PM
Contributor : Institut Pasteur Tunis <>
Submitted on : Monday, October 3, 2016 - 2:34:27 AM
Last modification on : Friday, October 23, 2020 - 9:22:31 PM
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