Immunochromatographic rK39 strip test in the serodiagnosis of visceral leishmaniasis in Tunisia

Abstract : The performance of the rK39 strip test in the diagnosis of Tunisian visceral leishmaniasis (VL) was evaluated and compared with that of immunofluorescent antibody test (IFAT). A total of 929 sera, including 574 from VL patients, 54 from cutaneous leishmaniasis (CL) patients, 42 from patients with other protozoan diseases, 152 from patients with non-parasitic diseases and 107 from healthy controls, were used in the study. The sensitivity and specificity of the rK39 strip test were 87.1 and 94.4%, respectively. Sixteen CL sera showed positive results, suggesting that the rK39 strip test is not restricted to Leishmania donovani complex detection. IFAT was comparatively more sensitive (98.9%) but slightly less specific (90.7%). Despite cross-reactivity shown by CL sera, the rK39 strip test can be recommended for the routine diagnosis of VL in Tunisia, as VL and CL are distinct clinical. entities. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.
Document type :
Journal articles
Complete list of metadatas

https://hal-riip.archives-ouvertes.fr/pasteur-01375330
Contributor : Institut Pasteur Tunis <>
Submitted on : Tuesday, January 10, 2017 - 1:40:34 PM
Last modification on : Monday, October 8, 2018 - 5:44:04 PM

Links full text

Identifiers

Collections

Citation

F. Saghrouni, S. Gaied-Meksi, A. Fathallah, F. Amri, H. Ach, et al.. Immunochromatographic rK39 strip test in the serodiagnosis of visceral leishmaniasis in Tunisia. Transactions of The Royal Society of Tropical Medicine and Hygiene, Oxford University Press (OUP), 2009, 103 (12), pp.1273-1278. ⟨10.1016/j.trstmh.2008.10.034⟩. ⟨pasteur-01375330⟩

Share

Metrics

Record views

60