[Evaluation and contribution of OptiMAL-IT® test for the diagnosis of imported malaria in Tunisia].

E Siala (1, 2) , H Foudhaili (1, 2) , A Doggi (2) , D Gamara (3) , N. Ben Alaya (4) , R. Ben Abdallah (1, 2) , H Tiouiri (5) , K. Aoun (1, 2) , A Bouratbine (1, 2)

1 Laboratoire de parasitologie-mycologie, parasitoses médicales, biotechnologie et biomolécules
2 LR11IPT06 - Laboratoire de Parasitologie Médicale, Biotechnologies et Biomolécules
3 Direction de soins de santé de base
4 Observatoire national des maladies nouvelles et émergentes, Tunis
5 Infectious Diseases Department

The rapid test OptiMAL-IT® was evaluated in the diagnosis and the screening of imported malaria in Tunisia in comparison with microscopic techniques. This prospective study focused on 500 individuals recruited from September 2010 to September 2012 in laboratory of Parasitology of Pasteur Institute of Tunis. They include 192 patients with clinical manifestations suggestive of malaria and 308 students originating from endemic areas. Microscopy of thick-and-thin blood smears and OptiMAL-IT® test were systematically performed on blood samples of all participants. Sixty individuals revealed infected by Plasmodium (12%). Positivity rates were respectively 20.3% in patients (44 cases) and 5.2% among asymptomatic students (16 cases) (p<0.01). The sensitivity and specificity of the OptiMAL-IT® test were respectively 88.6% and 100%. The concordance kappa was 0.92. The sensitivity and specificity during the screening of asymptomatic subjects were respectively 68.8% and 98.3% with a concordance of 0.67.

Domains: Life Sciences [q-bio]; Infectious diseases

E Siala, H Foudhaili, A Doggi, D Gamara, N. Ben Alaya, et al.. [Evaluation and contribution of OptiMAL-IT® test for the diagnosis of imported malaria in Tunisia].. Bulletin de la Société de pathologie exotique , 2013, 106 (4), pp.233-8. ⟨10.1007/s13149-013-0311-z⟩. ⟨pasteur-01382165⟩