D. Altomare and J. Testa, Perturbations of the AKT signaling pathway in human cancer, Oncogene, vol.11, issue.50, pp.7455-7464, 2005.
DOI : 10.1053/sonc.2002.34057

K. Arden, Multiple roles of FOXO transcription factors in mammalian cells point to multiple roles in cancer, Experimental Gerontology, vol.41, issue.8, pp.709-717, 2006.
DOI : 10.1016/j.exger.2006.05.015

S. Aroui, L. Dardevet, W. Ajmia, M. De-boisvilliers, F. Perrin et al., A Novel Platinum???Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway, Molecular Pharmaceutics, vol.12, issue.12, pp.4336-4348, 2015.
DOI : 10.1021/acs.molpharmaceut.5b00531

S. Aroui, N. Ram, F. Appaix, M. Ronjat, A. Kenani et al., Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231, Pharmaceutical Research, vol.106, issue.Pt 4, pp.836-845, 2009.
DOI : 10.1038/bjc.1993.452

URL : https://hal.archives-ouvertes.fr/inserm-00356481

S. Boreddy, K. Pramanik, and S. Srivastava, Pancreatic Tumor Suppression by Benzyl Isothiocyanate Is Associated with Inhibition of PI3K/AKT/FOXO Pathway, Clinical Cancer Research, vol.17, issue.7, pp.1784-1795, 2011.
DOI : 10.1158/1078-0432.CCR-10-1891

D. Calnan and A. Brunet, The FoxO code, Oncogene, vol.1769, issue.16, pp.2276-2288, 2008.
DOI : 10.1046/j.0022-3042.2002.00783.x

M. Carter and A. Brunet, FOXO transcription factors, Current Biology, vol.17, issue.4, pp.113-114, 2007.
DOI : 10.1016/j.cub.2007.01.008

A. Essafi, S. Fernandez-de-mattos, Y. Hassen, I. Soeiro, G. Mufti et al., Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells, Oncogene, vol.24, issue.14, pp.2317-2329, 2005.
DOI : 10.1038/sj.onc.1208421

E. Ferber, B. Peck, O. Delpuech, G. Bell, P. East et al., FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression, Cell Death and Differentiation, vol.19, issue.6, pp.968-979, 2011.
DOI : 10.1073/pnas.0506580102

M. Hollander, G. Blumenthal, and P. Dennis, PTEN loss in the continuum of common cancers, rare syndromes and mouse models, Nature Reviews Cancer, vol.9, issue.4, pp.289-301, 2011.
DOI : 10.1158/1535-7163.MCT-09-1012

A. Hussain, S. Uddin, R. Bu, O. Khan, S. Ahmed et al., Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines, PLoS ONE, vol.11, issue.9, p.24703, 2011.
DOI : 10.1371/journal.pone.0024703.s003

E. Lam, R. Francis, and M. Petkovic, FOXO transcription factors: key regulators of cell fate, Biochemical Society Transactions, vol.34, issue.5, pp.722-726, 2006.
DOI : 10.1042/BST0340722

J. Lopiccolo, G. Blumenthal, W. Bernstein, and P. Dennis, Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations, Drug Resistance Updates, vol.11, issue.1-2, pp.32-50, 2008.
DOI : 10.1016/j.drup.2007.11.003

H. Luo, Y. Yang, J. Duan, P. Wu, Q. Jiang et al., PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells, Cell Death and Disease, vol.17, issue.2, p.48, 2013.
DOI : 10.1007/s00277-008-0676-4

H. Margus, P. Arukuusk, U. Langel, and M. Pooga, Characteristics of Cell-Penetrating Peptide/Nucleic Acid Nanoparticles, Molecular Pharmaceutics, vol.13, issue.1, pp.172-179, 2015.
DOI : 10.1021/acs.molpharmaceut.5b00598

A. Messali, R. Villacorta, and J. Hay, A Review of the Economic Burden of Glioblastoma and the Cost Effectiveness of Pharmacologic Treatments, PharmacoEconomics, vol.11, issue.1, pp.1201-1212, 2014.
DOI : 10.1215/15228517-2008-078

O. Connor, L. Strasser, A. , O. Reilly, L. Hausmann et al., Bim: a novel member of the Bcl-2 family that promotes apoptosis, The EMBO Journal, vol.17, issue.2, pp.384-395, 1998.
DOI : 10.1093/emboj/17.2.384

P. Perret, M. Ahmadi, L. Riou, S. Bacot, J. Pecher et al., Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice, International Journal of Molecular Sciences, vol.21, issue.12, pp.27730-27740, 2015.
DOI : 10.1006/taap.2002.9432

P. Picone, D. Nuzzo, L. Caruana, E. Messina, V. Scafidi et al., Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation, Free Radical Research, vol.4, issue.12, pp.1397-1408, 2014.
DOI : 10.1038/cddis.2013.3

N. Ram, N. Weiss, I. Texier-nogues, S. Aroui, N. Andreotti et al., Design of a Disulfide-less, Pharmacologically Inert, and Chemically Competent Analog of Maurocalcine for the Efficient Transport of Impermeant Compounds into Cells, Journal of Biological Chemistry, vol.75, issue.40, pp.27048-27056, 2008.
DOI : 10.1074/jbc.M709971200

URL : https://hal.archives-ouvertes.fr/inserm-00355685

H. Roy, B. Olusola, D. Clemens, W. Karolski, A. Ratashak et al., AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis, Carcinogenesis, vol.23, issue.1, pp.201-205, 2002.
DOI : 10.1093/carcin/23.1.201

L. Salmena, A. Carracedo, and P. Pandolfi, Tenets of PTEN Tumor Suppression, Cell, vol.133, issue.3, pp.403-414, 2008.
DOI : 10.1016/j.cell.2008.04.013

G. Sharma, S. Kar, S. Palit, and P. Das, 18??-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells, Journal of Cellular Physiology, vol.1, issue.5, pp.1923-1931, 2012.
DOI : 10.1158/1535-7163.MCT-07-0434

A. Strasser, H. Puthalakath, P. Bouillet, D. Huang, O. Connor et al., The Role of Bim, a Proapoptotic BH3-Only Member of the Bcl-2 Family, in Cell-Death Control, Annals of the New York Academy of Sciences, vol.157, issue.1, 2000.
DOI : 10.1016/S0002-9440(10)64557-9

A. Sunters, P. Madureira, K. Pomeranz, M. Aubert, J. Brosens et al., -Terminal Kinase and Akt, Cancer Research, vol.66, issue.1, pp.212-220, 2006.
DOI : 10.1158/0008-5472.CAN-05-1997

S. Sykes, S. Lane, L. Bullinger, D. Kalaitzidis, R. Yusuf et al., AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias, Cell, vol.146, issue.5, pp.697-708, 2011.
DOI : 10.1016/j.cell.2011.07.032

K. Tsai, Y. Sun, C. Huang, J. Yang, M. Hung et al., Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification, Nucleic Acids Research, vol.35, issue.20, pp.6984-6994, 2007.
DOI : 10.1093/nar/gkm703

K. Van-der-vos, C. Gomez-puerto, and P. Coffer, Regulation of autophagy by Forkhead box (FOX) O transcription factors, Advances in Biological Regulation, vol.52, issue.1, pp.122-136, 2012.
DOI : 10.1016/j.advenzreg.2011.10.002

A. Van-gorp, K. Pomeranz, K. Birkenkamp, R. Hui, E. Lam et al., Chronic Protein Kinase B (PKB/c-akt) Activation Leads to Apoptosis Induced by Oxidative Stress-Mediated Foxo3a Transcriptional Up-regulation, Cancer Research, vol.66, issue.22, pp.10760-10769, 2006.
DOI : 10.1158/0008-5472.CAN-06-1111

J. Yang, C. Chang, W. Xia, Y. Wang, K. Wong et al., Activation of FOXO3a Is Sufficient to Reverse Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor Chemoresistance in Human Cancer, Cancer Research, vol.70, issue.11, pp.4709-4718, 2010.
DOI : 10.1158/0008-5472.CAN-09-4524

F. Wang, Y. Wang, Q. Cao, J. Zhang, L. Huang et al., Hydrogen peroxide induced impairment of endothelial progenitor cell viability is mediated through a FoxO3adependant mechanism, Microvasc Res, issue.90, pp.48-54, 2013.

J. Yang and H. Mc, A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer, Clinical Cancer Research, vol.15, issue.3, pp.752-757, 2009.
DOI : 10.1158/1078-0432.CCR-08-0124

J. Yang and H. Mc, Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy, Current Drug Targets, vol.12, issue.9, pp.1284-1290, 2011.
DOI : 10.2174/138945011796150299

S. Shukla, F. Rizvi, S. Raisuddin, and P. Kakkar, FoxO proteins??? nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells, Free Radical Biology and Medicine, vol.76, issue.6, pp.185-99, 2014.
DOI : 10.1016/j.freeradbiomed.2014.07.039