Fabrication of Electrochemical Model Influenza A Virus Biosensor Based on the Measurements of Neuroaminidase Enzyme Activity

Ülkü Anik; Yudum Tepeli; Mohamed F. Diouani

doi:10.1021/acs.analchem.6b01720

Fabrication of Electrochemical Model Influenza A Virus Biosensor Based on the Measurements of Neuroaminidase Enzyme Activity

Ülkü Anik ¹ Yudum Tepeli ¹ Mohamed F. Diouani ^{2, 3}

1 Mugla Sitki Kocman University

2 Institut Pasteur de Tunis

3 UTM - Université Tunis El Manar

Abstract : Neuroaminidase (NA) enzyme is a kind of glycoprotein that is found on the influenza A virus. During infection, NA is important for the release of influenza virions from the host cell surface together with viral aggregates. It may also be involved in targeting the virus to respiratory epithelial cells. In this study, a model electrochemical influenza A viral biosensor in which receptor-binding properties have been based on NA was developed for the first time. The biosensor's working principle is based on monitoring the interactions between fetuin A and NA enzyme. The assay was monitored step by step by using electrochemical impedance spectroscopy

Type de document :

Article dans une revue

Analytical Chemistry, American Chemical Society, 2016, 88 (12), pp.6151 - 6153. 〈10.1021/acs.analchem.6b01720〉

Domaine :

Sciences du Vivant [q-bio]

Chimie

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https://hal-riip.archives-ouvertes.fr/pasteur-01405788
Contributeur : Institut Pasteur Tunis <>
Soumis le : mercredi 30 novembre 2016 - 14:32:07
Dernière modification le : lundi 8 octobre 2018 - 17:44:08
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Fabrication of Electrochemical Model Influenza A Virus Biosensor Based on the Measurements of Neuroaminidase Enzyme Activity

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Fabrication of Electrochemical Model Influenza A Virus Biosensor Based on the Measurements of Neuroaminidase Enzyme Activity

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Citation

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77

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